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Chronic urticaria and thyroid autoimmunity: a meta-analysis of case–control studies

PURPOSE: Autoimmunity has been implicated in some patients with idiopathic chronic urticaria (CU). Because of the frequency of autoimmune thyroid diseases, their association with CU deserves special attention. We tested both the existence and the extent of an association between thyroid autoimmunity...

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Autores principales: Tienforti, D., Di Giulio, F., Spagnolo, L., Castellini, C., Totaro, M., Muselli, M., Francavilla, S., Baroni, M. G., Barbonetti, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184403/
https://www.ncbi.nlm.nih.gov/pubmed/35181847
http://dx.doi.org/10.1007/s40618-022-01761-2
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author Tienforti, D.
Di Giulio, F.
Spagnolo, L.
Castellini, C.
Totaro, M.
Muselli, M.
Francavilla, S.
Baroni, M. G.
Barbonetti, A.
author_facet Tienforti, D.
Di Giulio, F.
Spagnolo, L.
Castellini, C.
Totaro, M.
Muselli, M.
Francavilla, S.
Baroni, M. G.
Barbonetti, A.
author_sort Tienforti, D.
collection PubMed
description PURPOSE: Autoimmunity has been implicated in some patients with idiopathic chronic urticaria (CU). Because of the frequency of autoimmune thyroid diseases, their association with CU deserves special attention. We tested both the existence and the extent of an association between thyroid autoimmunity and CU. METHODS: A thorough search of PubMed, Scopus, Web of Science, and Cochrane databases was performed. Studies reporting the positivity rate for anti-thyroperoxidase antibodies (TPOAbs) in people with (cases) and without CU (controls) were included. Quality of the studies was assessed by the Newcastle–Ottawa Scale. Between-study heterogeneity was assessed by Cochrane Q and I(2) tests, and the odds ratio (OR) for TPOAbs positivity was combined using random-effects models. RESULTS: Nineteen studies provided information about TPOAbs positivity on 14,351 patients with CU and 12,404 controls. The pooled estimate indicated a more than fivefold increased risk of exhibiting TPOAbs positivity in the group with CU (pooled OR 5.18, 95% CI 3.27, 8.22; P < 0.00001). Correction for publication bias had a negligible effect on the overall estimate (pooled adjusted OR: 4.42, 95% CI 2.84, 6.87, P < 0.0001). Between‑study heterogeneity was established (I(2) = 62%, P(for heterogeneity) = 0.0002) and when, according to meta‑regression models, a sensitivity analysis was restricted to the 16 studies with the highest quality scores, the OR for TPOAbs positivity rose to 6.72 (95% CI 4.56, 9.89; P < 0.00001) with no significant heterogeneity (I(2) = 31%, P(for heterogeneity) = 0.11). CONCLUSIONS: Patients with CU have a five-to-nearly sevenfold higher risk of displaying TPOAbs positivity. All patients with CU may well be offered a screening for thyroid autoimmunity. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40618-022-01761-2.
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spelling pubmed-91844032022-06-11 Chronic urticaria and thyroid autoimmunity: a meta-analysis of case–control studies Tienforti, D. Di Giulio, F. Spagnolo, L. Castellini, C. Totaro, M. Muselli, M. Francavilla, S. Baroni, M. G. Barbonetti, A. J Endocrinol Invest Original Article PURPOSE: Autoimmunity has been implicated in some patients with idiopathic chronic urticaria (CU). Because of the frequency of autoimmune thyroid diseases, their association with CU deserves special attention. We tested both the existence and the extent of an association between thyroid autoimmunity and CU. METHODS: A thorough search of PubMed, Scopus, Web of Science, and Cochrane databases was performed. Studies reporting the positivity rate for anti-thyroperoxidase antibodies (TPOAbs) in people with (cases) and without CU (controls) were included. Quality of the studies was assessed by the Newcastle–Ottawa Scale. Between-study heterogeneity was assessed by Cochrane Q and I(2) tests, and the odds ratio (OR) for TPOAbs positivity was combined using random-effects models. RESULTS: Nineteen studies provided information about TPOAbs positivity on 14,351 patients with CU and 12,404 controls. The pooled estimate indicated a more than fivefold increased risk of exhibiting TPOAbs positivity in the group with CU (pooled OR 5.18, 95% CI 3.27, 8.22; P < 0.00001). Correction for publication bias had a negligible effect on the overall estimate (pooled adjusted OR: 4.42, 95% CI 2.84, 6.87, P < 0.0001). Between‑study heterogeneity was established (I(2) = 62%, P(for heterogeneity) = 0.0002) and when, according to meta‑regression models, a sensitivity analysis was restricted to the 16 studies with the highest quality scores, the OR for TPOAbs positivity rose to 6.72 (95% CI 4.56, 9.89; P < 0.00001) with no significant heterogeneity (I(2) = 31%, P(for heterogeneity) = 0.11). CONCLUSIONS: Patients with CU have a five-to-nearly sevenfold higher risk of displaying TPOAbs positivity. All patients with CU may well be offered a screening for thyroid autoimmunity. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40618-022-01761-2. Springer International Publishing 2022-02-18 2022 /pmc/articles/PMC9184403/ /pubmed/35181847 http://dx.doi.org/10.1007/s40618-022-01761-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Tienforti, D.
Di Giulio, F.
Spagnolo, L.
Castellini, C.
Totaro, M.
Muselli, M.
Francavilla, S.
Baroni, M. G.
Barbonetti, A.
Chronic urticaria and thyroid autoimmunity: a meta-analysis of case–control studies
title Chronic urticaria and thyroid autoimmunity: a meta-analysis of case–control studies
title_full Chronic urticaria and thyroid autoimmunity: a meta-analysis of case–control studies
title_fullStr Chronic urticaria and thyroid autoimmunity: a meta-analysis of case–control studies
title_full_unstemmed Chronic urticaria and thyroid autoimmunity: a meta-analysis of case–control studies
title_short Chronic urticaria and thyroid autoimmunity: a meta-analysis of case–control studies
title_sort chronic urticaria and thyroid autoimmunity: a meta-analysis of case–control studies
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184403/
https://www.ncbi.nlm.nih.gov/pubmed/35181847
http://dx.doi.org/10.1007/s40618-022-01761-2
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