Cargando…
Cognitive and Mood Profiles Among Patients With Stiff Person Syndrome Spectrum Disorders
An emerging body of evidence suggests that changes in cognitive and emotional function are common aspects of stiff person spectrum disorders (SPSD). We sought to examine the pattern of cognitive impairment and psychiatric symptoms in SPSD. METHODS: A retrospective review of medical records was condu...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184450/ https://www.ncbi.nlm.nih.gov/pubmed/35693022 http://dx.doi.org/10.3389/fneur.2022.865462 |
_version_ | 1784724520302542848 |
---|---|
author | Chan, Carol K. Pimentel Maldonado, Daniela A. Wang, Yujie Obando, Danielle Hughes, Abbey J. Newsome, Scott D. |
author_facet | Chan, Carol K. Pimentel Maldonado, Daniela A. Wang, Yujie Obando, Danielle Hughes, Abbey J. Newsome, Scott D. |
author_sort | Chan, Carol K. |
collection | PubMed |
description | An emerging body of evidence suggests that changes in cognitive and emotional function are common aspects of stiff person spectrum disorders (SPSD). We sought to examine the pattern of cognitive impairment and psychiatric symptoms in SPSD. METHODS: A retrospective review of medical records was conducted for patients seen at the Johns Hopkins Stiff Person Syndrome (SPS) center from 1997 to January 1st, 2020. Individuals who had received formal cognitive testing as part of routine clinical care for patient-reported cognitive changes were included. Demographics, prevalence of cognitive impairment, psychoactive medication use, and clinically significant psychiatric symptoms were described. RESULTS: Out of 205 patients screened, 20 completed cognitive testing (75% female, mean age 47.4 years). The most common domains of impairment were verbal learning and recall memory (n = 14, 70%), verbal fluency (n = 10, 50%), processing speed (n = 8, 40%), and attention (n = 8, 40%). 9/11 patients assessed for depression reported clinically significant symptoms, and 4/9 patients assessed for anxiety reported clinically significant symptoms. CONCLUSIONS: Screening for cognitive impairment in SPSD should utilize testing that assesses verbal learning and recall, phonemic verbal fluency, attention, and processing speed. Moreover, it is important to evaluate for co-existing depression and anxiety symptoms, as these are common in SPSD. |
format | Online Article Text |
id | pubmed-9184450 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91844502022-06-11 Cognitive and Mood Profiles Among Patients With Stiff Person Syndrome Spectrum Disorders Chan, Carol K. Pimentel Maldonado, Daniela A. Wang, Yujie Obando, Danielle Hughes, Abbey J. Newsome, Scott D. Front Neurol Neurology An emerging body of evidence suggests that changes in cognitive and emotional function are common aspects of stiff person spectrum disorders (SPSD). We sought to examine the pattern of cognitive impairment and psychiatric symptoms in SPSD. METHODS: A retrospective review of medical records was conducted for patients seen at the Johns Hopkins Stiff Person Syndrome (SPS) center from 1997 to January 1st, 2020. Individuals who had received formal cognitive testing as part of routine clinical care for patient-reported cognitive changes were included. Demographics, prevalence of cognitive impairment, psychoactive medication use, and clinically significant psychiatric symptoms were described. RESULTS: Out of 205 patients screened, 20 completed cognitive testing (75% female, mean age 47.4 years). The most common domains of impairment were verbal learning and recall memory (n = 14, 70%), verbal fluency (n = 10, 50%), processing speed (n = 8, 40%), and attention (n = 8, 40%). 9/11 patients assessed for depression reported clinically significant symptoms, and 4/9 patients assessed for anxiety reported clinically significant symptoms. CONCLUSIONS: Screening for cognitive impairment in SPSD should utilize testing that assesses verbal learning and recall, phonemic verbal fluency, attention, and processing speed. Moreover, it is important to evaluate for co-existing depression and anxiety symptoms, as these are common in SPSD. Frontiers Media S.A. 2022-05-27 /pmc/articles/PMC9184450/ /pubmed/35693022 http://dx.doi.org/10.3389/fneur.2022.865462 Text en Copyright © 2022 Chan, Pimentel Maldonado, Wang, Obando, Hughes and Newsome. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Chan, Carol K. Pimentel Maldonado, Daniela A. Wang, Yujie Obando, Danielle Hughes, Abbey J. Newsome, Scott D. Cognitive and Mood Profiles Among Patients With Stiff Person Syndrome Spectrum Disorders |
title | Cognitive and Mood Profiles Among Patients With Stiff Person Syndrome Spectrum Disorders |
title_full | Cognitive and Mood Profiles Among Patients With Stiff Person Syndrome Spectrum Disorders |
title_fullStr | Cognitive and Mood Profiles Among Patients With Stiff Person Syndrome Spectrum Disorders |
title_full_unstemmed | Cognitive and Mood Profiles Among Patients With Stiff Person Syndrome Spectrum Disorders |
title_short | Cognitive and Mood Profiles Among Patients With Stiff Person Syndrome Spectrum Disorders |
title_sort | cognitive and mood profiles among patients with stiff person syndrome spectrum disorders |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184450/ https://www.ncbi.nlm.nih.gov/pubmed/35693022 http://dx.doi.org/10.3389/fneur.2022.865462 |
work_keys_str_mv | AT chancarolk cognitiveandmoodprofilesamongpatientswithstiffpersonsyndromespectrumdisorders AT pimentelmaldonadodanielaa cognitiveandmoodprofilesamongpatientswithstiffpersonsyndromespectrumdisorders AT wangyujie cognitiveandmoodprofilesamongpatientswithstiffpersonsyndromespectrumdisorders AT obandodanielle cognitiveandmoodprofilesamongpatientswithstiffpersonsyndromespectrumdisorders AT hughesabbeyj cognitiveandmoodprofilesamongpatientswithstiffpersonsyndromespectrumdisorders AT newsomescottd cognitiveandmoodprofilesamongpatientswithstiffpersonsyndromespectrumdisorders |