Mitigation of SARS-CoV-2 transmission at a large public university

In Fall 2020, universities saw extensive transmission of SARS-CoV-2 among their populations, threatening health of the university and surrounding communities, and viability of in-person instruction. Here we report a case study at the University of Illinois at Urbana-Champaign, where a multimodal “SH...

Descripción completa

Detalles Bibliográficos
Autores principales: Ranoa, Diana Rose E., Holland, Robin L., Alnaji, Fadi G., Green, Kelsie J., Wang, Leyi, Fredrickson, Richard L., Wang, Tong, Wong, George N., Uelmen, Johnny, Maslov, Sergei, Weiner, Zachary J., Tkachenko, Alexei V., Zhang, Hantao, Liu, Zhiru, Ibrahim, Ahmed, Patel, Sanjay J., Paul, John M., Vance, Nickolas P., Gulick, Joseph G., Satheesan, Sandeep Puthanveetil, Galvan, Isaac J., Miller, Andrew, Grohens, Joseph, Nelson, Todd J., Stevens, Mary P., Hennessy, P Mark, Parker, Robert C., Santos, Edward, Brackett, Charles, Steinman, Julie D., Fenner, Melvin R., Dohrer, Kirstin, DeLorenzo, Michael, Wilhelm-Barr, Laura, Brauer, Brian R., Best-Popescu, Catherine, Durack, Gary, Wetter, Nathan, Kranz, David M., Breitbarth, Jessica, Simpson, Charlie, Pryde, Julie A., Kaler, Robin N., Harris, Chris, Vance, Allison C., Silotto, Jodi L., Johnson, Mark, Valera, Enrique Andres, Anton, Patricia K., Mwilambwe, Lowa, Bryan, Stephen P., Stone, Deborah S., Young, Danita B., Ward, Wanda E., Lantz, John, Vozenilek, John A., Bashir, Rashid, Moore, Jeffrey S., Garg, Mayank, Cooper, Julian C., Snyder, Gillian, Lore, Michelle H., Yocum, Dustin L., Cohen, Neal J., Novakofski, Jan E., Loots, Melanie J., Ballard, Randy L., Band, Mark, Banks, Kayla M., Barnes, Joseph D., Bentea, Iuliana, Black, Jessica, Busch, Jeremy, Conte, Abigail, Conte, Madison, Curry, Michael, Eardley, Jennifer, Edwards, April, Eggett, Therese, Fleurimont, Judes, Foster, Delaney, Fouke, Bruce W., Gallagher, Nicholas, Gastala, Nicole, Genung, Scott A., Glueck, Declan, Gray, Brittani, Greta, Andrew, Healy, Robert M., Hetrick, Ashley, Holterman, Arianna A., Ismail, Nahed, Jasenof, Ian, Kelly, Patrick, Kielbasa, Aaron, Kiesel, Teresa, Kindle, Lorenzo M., Lipking, Rhonda L., Manabe, Yukari C., Mayes, Jade ´, McGuffin, Reubin, McHenry, Kenton G., Mirza, Agha, Moseley, Jada, Mostafa, Heba H., Mumford, Melody, Munoz, Kathleen, Murray, Arika D., Nolan, Moira, Parikh, Nil A., Pekosz, Andrew, Pflugmacher, Janna, Phillips, Janise M., Pitts, Collin, Potter, Mark C., Quisenberry, James, Rear, Janelle, Robinson, Matthew L., Rosillo, Edith, Rye, Leslie N., Sherwood, MaryEllen, Simon, Anna, Singson, Jamie M., Skadden, Carly, Skelton, Tina H., Smith, Charlie, Stech, Mary, Thomas, Ryan, Tomaszewski, Matthew A., Tyburski, Erika A., Vanwingerden, Scott, Vlach, Evette, Watkins, Ronald S., Watson, Karriem, White, Karen C., Killeen, Timothy L., Jones, Robert J., Cangellaris, Andreas C., Martinis, Susan A., Vaid, Awais, Brooke, Christopher B., Walsh, Joseph T., Elbanna, Ahmed, Sullivan, William C., Smith, Rebecca L., Goldenfeld, Nigel, Fan, Timothy M., Hergenrother, Paul J., Burke, Martin D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184485/
https://www.ncbi.nlm.nih.gov/pubmed/35680861
http://dx.doi.org/10.1038/s41467-022-30833-3
Descripción
Sumario:In Fall 2020, universities saw extensive transmission of SARS-CoV-2 among their populations, threatening health of the university and surrounding communities, and viability of in-person instruction. Here we report a case study at the University of Illinois at Urbana-Champaign, where a multimodal “SHIELD: Target, Test, and Tell” program, with other non-pharmaceutical interventions, was employed to keep classrooms and laboratories open. The program included epidemiological modeling and surveillance, fast/frequent testing using a novel low-cost and scalable saliva-based RT-qPCR assay for SARS-CoV-2 that bypasses RNA extraction, called covidSHIELD, and digital tools for communication and compliance. In Fall 2020, we performed >1,000,000 covidSHIELD tests, positivity rates remained low, we had zero COVID-19-related hospitalizations or deaths amongst our university community, and mortality in the surrounding Champaign County was reduced more than 4-fold relative to expected. This case study shows that fast/frequent testing and other interventions mitigated transmission of SARS-CoV-2 at a large public university.

Ejemplares similares