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A Prediction Model for Peak Expiratory Flow Derived From Venous Blood Biomarkers and Clinical Factors in Amyotrophic Lateral Sclerosis

Although peripheral venous blood biomarkers are related to respiratory function in Amyotrophic lateral sclerosis (ALS) patients, there are still few prediction models that predict pulmonary function. This study aimed to investigate the venous blood biomarkers associated with respiratory function in...

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Autores principales: He, Xianghua, Feng, Jiaming, Cong, Xue, Huang, Hongyan, Zhao, Quanzhen, Shen, Qiuyan, Xu, Fang, Xu, Yanming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184518/
https://www.ncbi.nlm.nih.gov/pubmed/35692305
http://dx.doi.org/10.3389/fpubh.2022.899027
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author He, Xianghua
Feng, Jiaming
Cong, Xue
Huang, Hongyan
Zhao, Quanzhen
Shen, Qiuyan
Xu, Fang
Xu, Yanming
author_facet He, Xianghua
Feng, Jiaming
Cong, Xue
Huang, Hongyan
Zhao, Quanzhen
Shen, Qiuyan
Xu, Fang
Xu, Yanming
author_sort He, Xianghua
collection PubMed
description Although peripheral venous blood biomarkers are related to respiratory function in Amyotrophic lateral sclerosis (ALS) patients, there are still few prediction models that predict pulmonary function. This study aimed to investigate the venous blood biomarkers associated with respiratory function in patients with ALS from southwest China and to create prediction models based on those clinical biomarkers using logistic regression. A total of 319 patients with ALS from the retrospective cohort and 97 patients with ALS from the prospective cohort were enrolled in this study. A multivariable prediction model for the correlation between peak expiratory flow (PEF) and hematologic, biochemical laboratory parameters, and clinical factors in patients with ALS was created. Along with female patients, bulbar-onset, lower body mass index (BMI), later age of onset, lower level of creatinine, uric acid, triglyceride, and a higher level of high-density lipoprotein cholesterol (HDL_C) were related to reduced PEF. The area under the receiver operating characteristics (ROC) curve is.802 for the test set and.775 for the validation set. The study constructed a multivariable prediction model for PEF in patients with ALS. The results can be helpful for clinical practice to predict respiratory impairment.
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spelling pubmed-91845182022-06-11 A Prediction Model for Peak Expiratory Flow Derived From Venous Blood Biomarkers and Clinical Factors in Amyotrophic Lateral Sclerosis He, Xianghua Feng, Jiaming Cong, Xue Huang, Hongyan Zhao, Quanzhen Shen, Qiuyan Xu, Fang Xu, Yanming Front Public Health Public Health Although peripheral venous blood biomarkers are related to respiratory function in Amyotrophic lateral sclerosis (ALS) patients, there are still few prediction models that predict pulmonary function. This study aimed to investigate the venous blood biomarkers associated with respiratory function in patients with ALS from southwest China and to create prediction models based on those clinical biomarkers using logistic regression. A total of 319 patients with ALS from the retrospective cohort and 97 patients with ALS from the prospective cohort were enrolled in this study. A multivariable prediction model for the correlation between peak expiratory flow (PEF) and hematologic, biochemical laboratory parameters, and clinical factors in patients with ALS was created. Along with female patients, bulbar-onset, lower body mass index (BMI), later age of onset, lower level of creatinine, uric acid, triglyceride, and a higher level of high-density lipoprotein cholesterol (HDL_C) were related to reduced PEF. The area under the receiver operating characteristics (ROC) curve is.802 for the test set and.775 for the validation set. The study constructed a multivariable prediction model for PEF in patients with ALS. The results can be helpful for clinical practice to predict respiratory impairment. Frontiers Media S.A. 2022-05-27 /pmc/articles/PMC9184518/ /pubmed/35692305 http://dx.doi.org/10.3389/fpubh.2022.899027 Text en Copyright © 2022 He, Feng, Cong, Huang, Zhao, Shen, Xu and Xu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
He, Xianghua
Feng, Jiaming
Cong, Xue
Huang, Hongyan
Zhao, Quanzhen
Shen, Qiuyan
Xu, Fang
Xu, Yanming
A Prediction Model for Peak Expiratory Flow Derived From Venous Blood Biomarkers and Clinical Factors in Amyotrophic Lateral Sclerosis
title A Prediction Model for Peak Expiratory Flow Derived From Venous Blood Biomarkers and Clinical Factors in Amyotrophic Lateral Sclerosis
title_full A Prediction Model for Peak Expiratory Flow Derived From Venous Blood Biomarkers and Clinical Factors in Amyotrophic Lateral Sclerosis
title_fullStr A Prediction Model for Peak Expiratory Flow Derived From Venous Blood Biomarkers and Clinical Factors in Amyotrophic Lateral Sclerosis
title_full_unstemmed A Prediction Model for Peak Expiratory Flow Derived From Venous Blood Biomarkers and Clinical Factors in Amyotrophic Lateral Sclerosis
title_short A Prediction Model for Peak Expiratory Flow Derived From Venous Blood Biomarkers and Clinical Factors in Amyotrophic Lateral Sclerosis
title_sort prediction model for peak expiratory flow derived from venous blood biomarkers and clinical factors in amyotrophic lateral sclerosis
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184518/
https://www.ncbi.nlm.nih.gov/pubmed/35692305
http://dx.doi.org/10.3389/fpubh.2022.899027
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