Cargando…

Reduction of greenhouse gases emission through the use of tiletamine and zolazepam

Isoflurane is an anaesthetic gas widely used in both human and veterinary medicine. All currently used volatile anaesthetics are ozone-depleting halogenated compounds. The use of total intravenous anaesthesia (TIVA) allows to induce the effect of general anaesthesia by administering drugs only intra...

Descripción completa

Detalles Bibliográficos
Autores principales: Lachowska, Sonia, Antończyk, Agnieszka, Tunikowska, Joanna, Godniak, Martyna, Kiełbowicz, Zdzisław
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184519/
https://www.ncbi.nlm.nih.gov/pubmed/35681078
http://dx.doi.org/10.1038/s41598-022-13520-7
_version_ 1784724538127286272
author Lachowska, Sonia
Antończyk, Agnieszka
Tunikowska, Joanna
Godniak, Martyna
Kiełbowicz, Zdzisław
author_facet Lachowska, Sonia
Antończyk, Agnieszka
Tunikowska, Joanna
Godniak, Martyna
Kiełbowicz, Zdzisław
author_sort Lachowska, Sonia
collection PubMed
description Isoflurane is an anaesthetic gas widely used in both human and veterinary medicine. All currently used volatile anaesthetics are ozone-depleting halogenated compounds. The use of total intravenous anaesthesia (TIVA) allows to induce the effect of general anaesthesia by administering drugs only intravenously without the use of anaesthetic gases. This allows you to create a protocol that is safe not only for the patient, but also for doctors and the environment. However, so far, no anaesthetic protocol based on induction of anaesthesia with tiletamine-zolazepam without the need to maintain anaesthesia with anaesthetic gas has been developed. Our study showed that the use of this combination of drugs for induction does not require the use of additional isoflurane to maintain anaesthesia. Thanks to Dixon's up-and-down method we proved that with the induction of anaesthesia with tiletamine-zolazepam at a dose of 5 mg/kg the use of isoflurane is not needed to maintain anaesthesia in minimally invasive surgical procedures. Until now, this dose has been recommended by the producer for more diagnostic than surgical procedures or for induction of general anaesthesia. The maintenance was required with anaesthetic gas or administration of another dose of the tiletamine-zolazepam. The results obtained in this study will allow for a significant reduction in the consumption of isoflurane, a gas co-responsible for the deepening of the greenhouse effect, having a negative impact on patients and surgeons. These results are certainly the first step to achieving a well-balanced and safe TIVA-based anaesthetic protocol using tiletamine-zolazepam, the obvious goal of which will be to maximize both the safety of the patient, people involved in surgical procedures, and the environment itself. Being aware of the problem of the greenhouse effect, we are committed to reducing the consumption of anaesthetic gases by replacing them with infusion agents.
format Online
Article
Text
id pubmed-9184519
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-91845192022-06-11 Reduction of greenhouse gases emission through the use of tiletamine and zolazepam Lachowska, Sonia Antończyk, Agnieszka Tunikowska, Joanna Godniak, Martyna Kiełbowicz, Zdzisław Sci Rep Article Isoflurane is an anaesthetic gas widely used in both human and veterinary medicine. All currently used volatile anaesthetics are ozone-depleting halogenated compounds. The use of total intravenous anaesthesia (TIVA) allows to induce the effect of general anaesthesia by administering drugs only intravenously without the use of anaesthetic gases. This allows you to create a protocol that is safe not only for the patient, but also for doctors and the environment. However, so far, no anaesthetic protocol based on induction of anaesthesia with tiletamine-zolazepam without the need to maintain anaesthesia with anaesthetic gas has been developed. Our study showed that the use of this combination of drugs for induction does not require the use of additional isoflurane to maintain anaesthesia. Thanks to Dixon's up-and-down method we proved that with the induction of anaesthesia with tiletamine-zolazepam at a dose of 5 mg/kg the use of isoflurane is not needed to maintain anaesthesia in minimally invasive surgical procedures. Until now, this dose has been recommended by the producer for more diagnostic than surgical procedures or for induction of general anaesthesia. The maintenance was required with anaesthetic gas or administration of another dose of the tiletamine-zolazepam. The results obtained in this study will allow for a significant reduction in the consumption of isoflurane, a gas co-responsible for the deepening of the greenhouse effect, having a negative impact on patients and surgeons. These results are certainly the first step to achieving a well-balanced and safe TIVA-based anaesthetic protocol using tiletamine-zolazepam, the obvious goal of which will be to maximize both the safety of the patient, people involved in surgical procedures, and the environment itself. Being aware of the problem of the greenhouse effect, we are committed to reducing the consumption of anaesthetic gases by replacing them with infusion agents. Nature Publishing Group UK 2022-06-09 /pmc/articles/PMC9184519/ /pubmed/35681078 http://dx.doi.org/10.1038/s41598-022-13520-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Lachowska, Sonia
Antończyk, Agnieszka
Tunikowska, Joanna
Godniak, Martyna
Kiełbowicz, Zdzisław
Reduction of greenhouse gases emission through the use of tiletamine and zolazepam
title Reduction of greenhouse gases emission through the use of tiletamine and zolazepam
title_full Reduction of greenhouse gases emission through the use of tiletamine and zolazepam
title_fullStr Reduction of greenhouse gases emission through the use of tiletamine and zolazepam
title_full_unstemmed Reduction of greenhouse gases emission through the use of tiletamine and zolazepam
title_short Reduction of greenhouse gases emission through the use of tiletamine and zolazepam
title_sort reduction of greenhouse gases emission through the use of tiletamine and zolazepam
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184519/
https://www.ncbi.nlm.nih.gov/pubmed/35681078
http://dx.doi.org/10.1038/s41598-022-13520-7
work_keys_str_mv AT lachowskasonia reductionofgreenhousegasesemissionthroughtheuseoftiletamineandzolazepam
AT antonczykagnieszka reductionofgreenhousegasesemissionthroughtheuseoftiletamineandzolazepam
AT tunikowskajoanna reductionofgreenhousegasesemissionthroughtheuseoftiletamineandzolazepam
AT godniakmartyna reductionofgreenhousegasesemissionthroughtheuseoftiletamineandzolazepam
AT kiełbowiczzdzisław reductionofgreenhousegasesemissionthroughtheuseoftiletamineandzolazepam