Distinct dissociation rates of murine and human norovirus P-domain dimers suggest a role of dimer stability in virus-host interactions

Norovirus capsids are icosahedral particles composed of 90 dimers of the major capsid protein VP1. The C-terminus of the VP1 proteins forms a protruding (P)-domain, mediating receptor attachment, and providing a target for neutralizing antibodies. NMR and native mass spectrometry directly detect P-d...

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Detalles Bibliográficos
Autores principales: Creutznacher, Robert, Maass, Thorben, Dülfer, Jasmin, Feldmann, Clara, Hartmann, Veronika, Lane, Miranda Sophie, Knickmann, Jan, Westermann, Leon Torben, Thiede, Lars, Smith, Thomas J., Uetrecht, Charlotte, Mallagaray, Alvaro, Waudby, Christopher A., Taube, Stefan, Peters, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184547/
https://www.ncbi.nlm.nih.gov/pubmed/35680964
http://dx.doi.org/10.1038/s42003-022-03497-4

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