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An isogenic cell line panel for sequence-based screening of targeted anticancer drugs

We describe the creation of an isogenic cell line panel representing common cancer pathways, with features optimized for high-throughput screening. More than 1,800 cell lines from three normal human cell lines were generated using CRISPR technologies. Surprisingly, most of these lines did not result...

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Detalles Bibliográficos
Autores principales:	Cook, Ashley L., Wyhs, Nicolas, Sur, Surojit, Ptak, Blair, Popoli, Maria, Dobbyn, Laura, Papadopoulos, Tasos, Bettegowda, Chetan, Papadopoulos, Nickolas, Vogelstein, Bert, Zhou, Shibin, Kinzler, Kenneth W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184558/ https://www.ncbi.nlm.nih.gov/pubmed/35692635 http://dx.doi.org/10.1016/j.isci.2022.104437

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