Molecular mechanisms of exceptional lifespan increase of Drosophila melanogaster with different genotypes after combinations of pro-longevity interventions

Aging is one of the global challenges of our time. The search for new anti-aging interventions is also an issue of great actuality. We report on the success of Drosophila melanogaster lifespan extension under the combined influence of dietary restriction, co-administration of berberine, fucoxanthin,...

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Detalles Bibliográficos
Autores principales: Shaposhnikov, Mikhail V., Guvatova, Zulfiya G., Zemskaya, Nadezhda V., Koval, Liubov A., Schegoleva, Eugenia V., Gorbunova, Anastasia A., Golubev, Denis A., Pakshina, Natalya R., Ulyasheva, Natalia S., Solovev, Ilya A., Bobrovskikh, Margarita A., Gruntenko, Nataly E., Menshanov, Petr N., Krasnov, George S., Kudryavseva, Anna V., Moskalev, Alexey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184560/
https://www.ncbi.nlm.nih.gov/pubmed/35681084
http://dx.doi.org/10.1038/s42003-022-03524-4
Descripción
Sumario:Aging is one of the global challenges of our time. The search for new anti-aging interventions is also an issue of great actuality. We report on the success of Drosophila melanogaster lifespan extension under the combined influence of dietary restriction, co-administration of berberine, fucoxanthin, and rapamycin, photodeprivation, and low-temperature conditions up to 185 days in w(1118) strain and up to 213 days in long-lived E(z)/w mutants. The trade-off was found between longevity and locomotion. The transcriptome analysis showed an impact of epigenetic alterations, lipid metabolism, cellular respiration, nutrient sensing, immune response, and autophagy in the registered effect.

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