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eEF2K Activity Determines Synergy to Cotreatment of Cancer Cells With PI3K and MEK Inhibitors

PI3K-mammalian target of rapamycin and MAPK/ERK kinase (MEK)/mitogen-activated protein kinase (MAPK) are the most frequently dysregulated signaling pathways in cancer. A problem that limits the success of therapies that target individual PI3K-MAPK members is that these pathways converge to regulate...

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Detalles Bibliográficos
Autores principales:	Hijazi, Maruan, Casado, Pedro, Akhtar, Nosheen, Alvarez-Teijeiro, Saul, Rajeeve, Vinothini, Cutillas, Pedro R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184568/ https://www.ncbi.nlm.nih.gov/pubmed/35513296 http://dx.doi.org/10.1016/j.mcpro.2022.100240

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