TAS1553, a small molecule subunit interaction inhibitor of ribonucleotide reductase, exhibits antitumor activity by causing DNA replication stress

Ribonucleotide reductase (RNR) is composed of two non-identical subunits, R1 and R2, and plays a crucial role in balancing the cellular dNTP pool, establishing it as an attractive cancer target. Herein, we report the discovery of a highly potent and selective small-molecule inhibitor, TAS1553, targe...

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Detalles Bibliográficos
Autores principales: Ueno, Hiroyuki, Hoshino, Takuya, Yano, Wakako, Tsukioka, Sayaka, Suzuki, Takamasa, Hara, Shoki, Ogino, Yoshio, Chong, Khoon Tee, Suzuki, Tatsuya, Tsuji, Shingo, Itadani, Hikaru, Yamamiya, Ikuo, Otsu, Yoshihiro, Ito, Satoshi, Yonekura, Toshiya, Terasaka, Miki, Tanaka, Nozomu, Miyahara, Seiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184620/
https://www.ncbi.nlm.nih.gov/pubmed/35681099
http://dx.doi.org/10.1038/s42003-022-03516-4

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