Mechanically active integrins target lytic secretion at the immune synapse to facilitate cellular cytotoxicity

Cytotoxic lymphocytes fight pathogens and cancer by forming immune synapses with infected or transformed target cells and then secreting cytotoxic perforin and granzyme into the synaptic space, with potent and specific killing achieved by this focused delivery. The mechanisms that establish the prec...

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Detalles Bibliográficos
Autores principales: Wang, Mitchell S., Hu, Yuesong, Sanchez, Elisa E., Xie, Xihe, Roy, Nathan H., de Jesus, Miguel, Winer, Benjamin Y., Zale, Elizabeth A., Jin, Weiyang, Sachar, Chirag, Lee, Joanne H., Hong, Yeonsun, Kim, Minsoo, Kam, Lance C., Salaita, Khalid, Huse, Morgan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184626/
https://www.ncbi.nlm.nih.gov/pubmed/35680882
http://dx.doi.org/10.1038/s41467-022-30809-3

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