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Porcine Functional Spine Unit in orthopedic research, a systematic scoping review of the methodology

PURPOSE: The aim of this study was to conduct a systematic scoping review of previous in vitro spine studies that used pig functional spinal units (FSU) as a model to gain an understanding of how different experimental methods are presented in the literature. Research guidelines are often used to ac...

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Autores principales: Hedlund, Jacob, Ekström, Lars, Thoreson, Olof
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184692/
https://www.ncbi.nlm.nih.gov/pubmed/35678892
http://dx.doi.org/10.1186/s40634-022-00488-6
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author Hedlund, Jacob
Ekström, Lars
Thoreson, Olof
author_facet Hedlund, Jacob
Ekström, Lars
Thoreson, Olof
author_sort Hedlund, Jacob
collection PubMed
description PURPOSE: The aim of this study was to conduct a systematic scoping review of previous in vitro spine studies that used pig functional spinal units (FSU) as a model to gain an understanding of how different experimental methods are presented in the literature. Research guidelines are often used to achieve high quality in methods, results, and reports, but no research guidelines are available regarding in vitro biomechanical spinal studies. METHODS: A systematic scoping review approach and protocol was used for the study with a systematic search in several data bases combined with an extra author search. The articles were examined in multiple stages by two different authors in a blinded manner. Data was extracted from the included articles and inserted into a previously crafted matrix with multiple variables. The data was analyzed to evaluate study methods and quality and included 70 studies. RESULTS: The results display that there is a lack of consensus regarding how the material, methods and results are presented. Load type, duration and magnitude were heterogeneous among the studies, but sixty-seven studies (96%) did include compressive load or tension in the testing protocol. CONCLUSIONS: This study concludes that an improvement of reported data in the present field of research is needed. A protocol, modified from the ARRIVE guidelines, regarding enhanced report-structure, that would enable comparison between studies and improve the method quality is presented in the current study. There is also a clear need for a validated quality-assessment template for experimental animal studies.
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spelling pubmed-91846922022-06-11 Porcine Functional Spine Unit in orthopedic research, a systematic scoping review of the methodology Hedlund, Jacob Ekström, Lars Thoreson, Olof J Exp Orthop Review Paper PURPOSE: The aim of this study was to conduct a systematic scoping review of previous in vitro spine studies that used pig functional spinal units (FSU) as a model to gain an understanding of how different experimental methods are presented in the literature. Research guidelines are often used to achieve high quality in methods, results, and reports, but no research guidelines are available regarding in vitro biomechanical spinal studies. METHODS: A systematic scoping review approach and protocol was used for the study with a systematic search in several data bases combined with an extra author search. The articles were examined in multiple stages by two different authors in a blinded manner. Data was extracted from the included articles and inserted into a previously crafted matrix with multiple variables. The data was analyzed to evaluate study methods and quality and included 70 studies. RESULTS: The results display that there is a lack of consensus regarding how the material, methods and results are presented. Load type, duration and magnitude were heterogeneous among the studies, but sixty-seven studies (96%) did include compressive load or tension in the testing protocol. CONCLUSIONS: This study concludes that an improvement of reported data in the present field of research is needed. A protocol, modified from the ARRIVE guidelines, regarding enhanced report-structure, that would enable comparison between studies and improve the method quality is presented in the current study. There is also a clear need for a validated quality-assessment template for experimental animal studies. Springer Berlin Heidelberg 2022-06-09 /pmc/articles/PMC9184692/ /pubmed/35678892 http://dx.doi.org/10.1186/s40634-022-00488-6 Text en © The Author(s) 2022, corrected publication 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Paper
Hedlund, Jacob
Ekström, Lars
Thoreson, Olof
Porcine Functional Spine Unit in orthopedic research, a systematic scoping review of the methodology
title Porcine Functional Spine Unit in orthopedic research, a systematic scoping review of the methodology
title_full Porcine Functional Spine Unit in orthopedic research, a systematic scoping review of the methodology
title_fullStr Porcine Functional Spine Unit in orthopedic research, a systematic scoping review of the methodology
title_full_unstemmed Porcine Functional Spine Unit in orthopedic research, a systematic scoping review of the methodology
title_short Porcine Functional Spine Unit in orthopedic research, a systematic scoping review of the methodology
title_sort porcine functional spine unit in orthopedic research, a systematic scoping review of the methodology
topic Review Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184692/
https://www.ncbi.nlm.nih.gov/pubmed/35678892
http://dx.doi.org/10.1186/s40634-022-00488-6
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