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Generalized Edema and Pseudothrombocytopenia After ChAdOx1 nCoV-19 COVID-19 Vaccination: A Case Report
Reports of side effects of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are increasing worldwide. Capillary leak syndrome and vaccine-induced immune thrombotic thrombocytopenia are very rare but life-threatening adverse events that should be identified early and trea...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184712/ https://www.ncbi.nlm.nih.gov/pubmed/35692333 http://dx.doi.org/10.3389/fpubh.2022.907652 |
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author | Bokel, Joanna Mendes-de-Almeida, Daniela P. Martins-Gonçalves, Remy Palhinha, Lohanna Vizzoni, Alexandre G. Correa, Danusa Ferreira Brandão, Luciana Gomes Pedro Bozza, Patrícia T. Grinsztejn, Beatriz |
author_facet | Bokel, Joanna Mendes-de-Almeida, Daniela P. Martins-Gonçalves, Remy Palhinha, Lohanna Vizzoni, Alexandre G. Correa, Danusa Ferreira Brandão, Luciana Gomes Pedro Bozza, Patrícia T. Grinsztejn, Beatriz |
author_sort | Bokel, Joanna |
collection | PubMed |
description | Reports of side effects of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are increasing worldwide. Capillary leak syndrome and vaccine-induced immune thrombotic thrombocytopenia are very rare but life-threatening adverse events that should be identified early and treated. However, isolated thrombocytopenia can indicate pseudothrombocytopenia. In certain people, ethylenediaminetetraacetic acid (EDTA) induces an in vitro platelet aggregation, resulting in misleading underestimation of platelet counts. It is essential to recognize pseudothrombocytopenia to prevent diagnostic errors, overtreatment, anxiety, and unnecessary invasive procedures. We present a case who developed generalized edema and persistent pseudothrombocytopenia after the first dose of the ChAdOx1 nCoV-19 vaccine (AstraZeneca). |
format | Online Article Text |
id | pubmed-9184712 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91847122022-06-11 Generalized Edema and Pseudothrombocytopenia After ChAdOx1 nCoV-19 COVID-19 Vaccination: A Case Report Bokel, Joanna Mendes-de-Almeida, Daniela P. Martins-Gonçalves, Remy Palhinha, Lohanna Vizzoni, Alexandre G. Correa, Danusa Ferreira Brandão, Luciana Gomes Pedro Bozza, Patrícia T. Grinsztejn, Beatriz Front Public Health Public Health Reports of side effects of vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are increasing worldwide. Capillary leak syndrome and vaccine-induced immune thrombotic thrombocytopenia are very rare but life-threatening adverse events that should be identified early and treated. However, isolated thrombocytopenia can indicate pseudothrombocytopenia. In certain people, ethylenediaminetetraacetic acid (EDTA) induces an in vitro platelet aggregation, resulting in misleading underestimation of platelet counts. It is essential to recognize pseudothrombocytopenia to prevent diagnostic errors, overtreatment, anxiety, and unnecessary invasive procedures. We present a case who developed generalized edema and persistent pseudothrombocytopenia after the first dose of the ChAdOx1 nCoV-19 vaccine (AstraZeneca). Frontiers Media S.A. 2022-05-27 /pmc/articles/PMC9184712/ /pubmed/35692333 http://dx.doi.org/10.3389/fpubh.2022.907652 Text en Copyright © 2022 Bokel, Mendes-de-Almeida, Martins-Gonçalves, Palhinha, Vizzoni, Correa, Brandão, Bozza and Grinsztejn. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Public Health Bokel, Joanna Mendes-de-Almeida, Daniela P. Martins-Gonçalves, Remy Palhinha, Lohanna Vizzoni, Alexandre G. Correa, Danusa Ferreira Brandão, Luciana Gomes Pedro Bozza, Patrícia T. Grinsztejn, Beatriz Generalized Edema and Pseudothrombocytopenia After ChAdOx1 nCoV-19 COVID-19 Vaccination: A Case Report |
title | Generalized Edema and Pseudothrombocytopenia After ChAdOx1 nCoV-19 COVID-19 Vaccination: A Case Report |
title_full | Generalized Edema and Pseudothrombocytopenia After ChAdOx1 nCoV-19 COVID-19 Vaccination: A Case Report |
title_fullStr | Generalized Edema and Pseudothrombocytopenia After ChAdOx1 nCoV-19 COVID-19 Vaccination: A Case Report |
title_full_unstemmed | Generalized Edema and Pseudothrombocytopenia After ChAdOx1 nCoV-19 COVID-19 Vaccination: A Case Report |
title_short | Generalized Edema and Pseudothrombocytopenia After ChAdOx1 nCoV-19 COVID-19 Vaccination: A Case Report |
title_sort | generalized edema and pseudothrombocytopenia after chadox1 ncov-19 covid-19 vaccination: a case report |
topic | Public Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184712/ https://www.ncbi.nlm.nih.gov/pubmed/35692333 http://dx.doi.org/10.3389/fpubh.2022.907652 |
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