Prevalence of Y chromosome microdeletions among infertile Mongolian men

OBJECTIVE: Y chromosome microdeletions are the second most common genetic cause of male infertility after Klinefelter syndrome. The aim of this study was to determine the patterns of Y chromosome microdeletions among infertile Mongolian men. METHODS: A descriptive study was performed on 75 infertile...

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Detalles Bibliográficos
Autores principales: Damdinsuren, Erdenesuvd, Naidansuren, Purevjargal, Gochoo, Mendsaikhan, Choi, Bum-Chae, Choi, Min-Youp, Baldandorj, Bolorchimeg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Reproductive Medicine 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184878/
https://www.ncbi.nlm.nih.gov/pubmed/35698772
http://dx.doi.org/10.5653/cerm.2021.05099
Descripción
Sumario:OBJECTIVE: Y chromosome microdeletions are the second most common genetic cause of male infertility after Klinefelter syndrome. The aim of this study was to determine the patterns of Y chromosome microdeletions among infertile Mongolian men. METHODS: A descriptive study was performed on 75 infertile men from February 2017 to December 2018. Y chromosome microdeletions were identified by polymerase chain reaction. Semen parameters, hormonal levels, and testis biopsy samples were examined. RESULTS: Among 75 infertile men, two cases of Y chromosome microdeletions were identified. The first case had an AZFa complete deletion and the other had an AZFc partial deletion. This study found that the proportion of Y chromosome microdeletions among infertile Mongolian men was 2.66%. CONCLUSION: The findings can be applied to in vitro fertilization and assisted reproductive technology, and our results will help clinicians improve treatment management for infertile Mongolian couples.

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