Cargando…
The impact of hyperandrogenism on the outcomes of ovulation induction using gonadotropin and intrauterine insemination in women with polycystic ovary syndrome
OBJECTIVE: This study aimed to investigate the impact of hyperandrogenism (HA) on the outcomes of ovulation induction (OI) using gonadotropin and intrauterine insemination (IUI) in patients with polycystic ovary syndrome (PCOS). METHODS: This was a retrospective cohort study including 415 patients u...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Reproductive Medicine
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184886/ https://www.ncbi.nlm.nih.gov/pubmed/35698775 http://dx.doi.org/10.5653/cerm.2022.05204 |
_version_ | 1784724628362493952 |
---|---|
author | Ho, Vu Ngoc Anh Pham, Toan Duong Nguyen, Nam Thanh Hoang, Hieu Le Trung Ho, Tuong Manh Vuong, Lan Ngoc |
author_facet | Ho, Vu Ngoc Anh Pham, Toan Duong Nguyen, Nam Thanh Hoang, Hieu Le Trung Ho, Tuong Manh Vuong, Lan Ngoc |
author_sort | Ho, Vu Ngoc Anh |
collection | PubMed |
description | OBJECTIVE: This study aimed to investigate the impact of hyperandrogenism (HA) on the outcomes of ovulation induction (OI) using gonadotropin and intrauterine insemination (IUI) in patients with polycystic ovary syndrome (PCOS). METHODS: This was a retrospective cohort study including 415 patients undergoing OI using gonadotropin and IUI treatment between January 2018 and December 2020 at a single infertility center. Baseline characteristics, clinical and laboratory parameters, and pregnancy outcomes were investigated. RESULTS: Among the study population, there were 105 hyperandrogenic (25.3%) and 310 non-hyperandrogenic patients (74.7%). The live birth rate was lower in the HA group than in the non-HA group, but this difference did not reach statistical significance due to the limited sample size (14.3% vs. 21.0%, relative risk=0.68; 95% CI, 0.41–1.14, p=0.153). No predictive factors for live birth were identified through logistic regression analysis. CONCLUSION: HA did not negatively affect the outcomes of OI using gonadotropin and IUI cycles in Vietnamese women with PCOS. The result may not be applicable elsewhere due to the large variation in the characteristics of women with PCOS across races and populations. |
format | Online Article Text |
id | pubmed-9184886 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Korean Society for Reproductive Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-91848862022-06-14 The impact of hyperandrogenism on the outcomes of ovulation induction using gonadotropin and intrauterine insemination in women with polycystic ovary syndrome Ho, Vu Ngoc Anh Pham, Toan Duong Nguyen, Nam Thanh Hoang, Hieu Le Trung Ho, Tuong Manh Vuong, Lan Ngoc Clin Exp Reprod Med Original Article OBJECTIVE: This study aimed to investigate the impact of hyperandrogenism (HA) on the outcomes of ovulation induction (OI) using gonadotropin and intrauterine insemination (IUI) in patients with polycystic ovary syndrome (PCOS). METHODS: This was a retrospective cohort study including 415 patients undergoing OI using gonadotropin and IUI treatment between January 2018 and December 2020 at a single infertility center. Baseline characteristics, clinical and laboratory parameters, and pregnancy outcomes were investigated. RESULTS: Among the study population, there were 105 hyperandrogenic (25.3%) and 310 non-hyperandrogenic patients (74.7%). The live birth rate was lower in the HA group than in the non-HA group, but this difference did not reach statistical significance due to the limited sample size (14.3% vs. 21.0%, relative risk=0.68; 95% CI, 0.41–1.14, p=0.153). No predictive factors for live birth were identified through logistic regression analysis. CONCLUSION: HA did not negatively affect the outcomes of OI using gonadotropin and IUI cycles in Vietnamese women with PCOS. The result may not be applicable elsewhere due to the large variation in the characteristics of women with PCOS across races and populations. Korean Society for Reproductive Medicine 2022-06 2022-05-27 /pmc/articles/PMC9184886/ /pubmed/35698775 http://dx.doi.org/10.5653/cerm.2022.05204 Text en Copyright © 2022. THE KOREAN SOCIETY FOR REPRODUCTIVE MEDICINE https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Ho, Vu Ngoc Anh Pham, Toan Duong Nguyen, Nam Thanh Hoang, Hieu Le Trung Ho, Tuong Manh Vuong, Lan Ngoc The impact of hyperandrogenism on the outcomes of ovulation induction using gonadotropin and intrauterine insemination in women with polycystic ovary syndrome |
title | The impact of hyperandrogenism on the outcomes of ovulation induction using gonadotropin and intrauterine insemination in women with polycystic ovary syndrome |
title_full | The impact of hyperandrogenism on the outcomes of ovulation induction using gonadotropin and intrauterine insemination in women with polycystic ovary syndrome |
title_fullStr | The impact of hyperandrogenism on the outcomes of ovulation induction using gonadotropin and intrauterine insemination in women with polycystic ovary syndrome |
title_full_unstemmed | The impact of hyperandrogenism on the outcomes of ovulation induction using gonadotropin and intrauterine insemination in women with polycystic ovary syndrome |
title_short | The impact of hyperandrogenism on the outcomes of ovulation induction using gonadotropin and intrauterine insemination in women with polycystic ovary syndrome |
title_sort | impact of hyperandrogenism on the outcomes of ovulation induction using gonadotropin and intrauterine insemination in women with polycystic ovary syndrome |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9184886/ https://www.ncbi.nlm.nih.gov/pubmed/35698775 http://dx.doi.org/10.5653/cerm.2022.05204 |
work_keys_str_mv | AT hovungocanh theimpactofhyperandrogenismontheoutcomesofovulationinductionusinggonadotropinandintrauterineinseminationinwomenwithpolycysticovarysyndrome AT phamtoanduong theimpactofhyperandrogenismontheoutcomesofovulationinductionusinggonadotropinandintrauterineinseminationinwomenwithpolycysticovarysyndrome AT nguyennamthanh theimpactofhyperandrogenismontheoutcomesofovulationinductionusinggonadotropinandintrauterineinseminationinwomenwithpolycysticovarysyndrome AT hoanghieuletrung theimpactofhyperandrogenismontheoutcomesofovulationinductionusinggonadotropinandintrauterineinseminationinwomenwithpolycysticovarysyndrome AT hotuongmanh theimpactofhyperandrogenismontheoutcomesofovulationinductionusinggonadotropinandintrauterineinseminationinwomenwithpolycysticovarysyndrome AT vuonglanngoc theimpactofhyperandrogenismontheoutcomesofovulationinductionusinggonadotropinandintrauterineinseminationinwomenwithpolycysticovarysyndrome AT hovungocanh impactofhyperandrogenismontheoutcomesofovulationinductionusinggonadotropinandintrauterineinseminationinwomenwithpolycysticovarysyndrome AT phamtoanduong impactofhyperandrogenismontheoutcomesofovulationinductionusinggonadotropinandintrauterineinseminationinwomenwithpolycysticovarysyndrome AT nguyennamthanh impactofhyperandrogenismontheoutcomesofovulationinductionusinggonadotropinandintrauterineinseminationinwomenwithpolycysticovarysyndrome AT hoanghieuletrung impactofhyperandrogenismontheoutcomesofovulationinductionusinggonadotropinandintrauterineinseminationinwomenwithpolycysticovarysyndrome AT hotuongmanh impactofhyperandrogenismontheoutcomesofovulationinductionusinggonadotropinandintrauterineinseminationinwomenwithpolycysticovarysyndrome AT vuonglanngoc impactofhyperandrogenismontheoutcomesofovulationinductionusinggonadotropinandintrauterineinseminationinwomenwithpolycysticovarysyndrome |