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Risk factors associated with bacteremia in COVID-19 patients admitted to intensive care unit: a retrospective multicenter cohort study

PURPOSE: This multicenter observational study was done to evaluate risk factors related to the development of BSI in patients admitted to ICU for COVID-19. METHODS: All patients with COVID-19 admitted in two COVID-19 dedicated ICUs in two different hospital between 02–2020 and 02–2021 were recruited...

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Autores principales: Bonazzetti, Cecilia, Rinaldi, Matteo, Giacomelli, Andrea, Colombo, Riccardo, Ottolina, Davide, Rimoldi, Sara Giordana, Pagani, Cristina, Morena, Valentina, Ridolfo, Anna Lisa, Vatamanu, Oana, Giacomini, Maria Eugenia, Campoli, Caterina, Oreni, Letizia, Rizzardini, Giuliano, Viale, Pierluigi, Antinori, Spinello, Giannella, Maddalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185127/
https://www.ncbi.nlm.nih.gov/pubmed/35687293
http://dx.doi.org/10.1007/s15010-022-01853-4
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author Bonazzetti, Cecilia
Rinaldi, Matteo
Giacomelli, Andrea
Colombo, Riccardo
Ottolina, Davide
Rimoldi, Sara Giordana
Pagani, Cristina
Morena, Valentina
Ridolfo, Anna Lisa
Vatamanu, Oana
Giacomini, Maria Eugenia
Campoli, Caterina
Oreni, Letizia
Rizzardini, Giuliano
Viale, Pierluigi
Antinori, Spinello
Giannella, Maddalena
author_facet Bonazzetti, Cecilia
Rinaldi, Matteo
Giacomelli, Andrea
Colombo, Riccardo
Ottolina, Davide
Rimoldi, Sara Giordana
Pagani, Cristina
Morena, Valentina
Ridolfo, Anna Lisa
Vatamanu, Oana
Giacomini, Maria Eugenia
Campoli, Caterina
Oreni, Letizia
Rizzardini, Giuliano
Viale, Pierluigi
Antinori, Spinello
Giannella, Maddalena
author_sort Bonazzetti, Cecilia
collection PubMed
description PURPOSE: This multicenter observational study was done to evaluate risk factors related to the development of BSI in patients admitted to ICU for COVID-19. METHODS: All patients with COVID-19 admitted in two COVID-19 dedicated ICUs in two different hospital between 02–2020 and 02–2021 were recruited. RESULT: 537 patients were included of whom 265 (49.3%) experienced at least one BSI. Patients who developed bacteremia had a higher SOFA score [10 (8–12) vs 9 (7–10), p < 0.001], had been intubated more frequently [95.8% vs 75%, p < 0.001] and for a median longer time [16 days (9–25) vs 8 days (5–14), p < 0.001]. Patients with BSI had a median longer ICU stay [18 days (12–31.5) vs 9 days (5–15), p < 0.001] and higher mortality [54% vs 42.3%, p < 0.001] than those who did not develop it. Development of BSI resulted in a higher SOFA score [aHR 1.08 (95% CI 1.03–1.12)] and a higher Charlson score [csAHR 1.15 (95% CI 1.05–1.25)]. CONCLUSION: A high SOFA score and a high Charlson score resulted associated with BSI’s development. Conversely, immunosuppressive therapy like steroids and tocilizumab, has no role in increasing the risk of bacteremia. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s15010-022-01853-4.
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spelling pubmed-91851272022-06-10 Risk factors associated with bacteremia in COVID-19 patients admitted to intensive care unit: a retrospective multicenter cohort study Bonazzetti, Cecilia Rinaldi, Matteo Giacomelli, Andrea Colombo, Riccardo Ottolina, Davide Rimoldi, Sara Giordana Pagani, Cristina Morena, Valentina Ridolfo, Anna Lisa Vatamanu, Oana Giacomini, Maria Eugenia Campoli, Caterina Oreni, Letizia Rizzardini, Giuliano Viale, Pierluigi Antinori, Spinello Giannella, Maddalena Infection Original Paper PURPOSE: This multicenter observational study was done to evaluate risk factors related to the development of BSI in patients admitted to ICU for COVID-19. METHODS: All patients with COVID-19 admitted in two COVID-19 dedicated ICUs in two different hospital between 02–2020 and 02–2021 were recruited. RESULT: 537 patients were included of whom 265 (49.3%) experienced at least one BSI. Patients who developed bacteremia had a higher SOFA score [10 (8–12) vs 9 (7–10), p < 0.001], had been intubated more frequently [95.8% vs 75%, p < 0.001] and for a median longer time [16 days (9–25) vs 8 days (5–14), p < 0.001]. Patients with BSI had a median longer ICU stay [18 days (12–31.5) vs 9 days (5–15), p < 0.001] and higher mortality [54% vs 42.3%, p < 0.001] than those who did not develop it. Development of BSI resulted in a higher SOFA score [aHR 1.08 (95% CI 1.03–1.12)] and a higher Charlson score [csAHR 1.15 (95% CI 1.05–1.25)]. CONCLUSION: A high SOFA score and a high Charlson score resulted associated with BSI’s development. Conversely, immunosuppressive therapy like steroids and tocilizumab, has no role in increasing the risk of bacteremia. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s15010-022-01853-4. Springer Berlin Heidelberg 2022-06-10 2023 /pmc/articles/PMC9185127/ /pubmed/35687293 http://dx.doi.org/10.1007/s15010-022-01853-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Paper
Bonazzetti, Cecilia
Rinaldi, Matteo
Giacomelli, Andrea
Colombo, Riccardo
Ottolina, Davide
Rimoldi, Sara Giordana
Pagani, Cristina
Morena, Valentina
Ridolfo, Anna Lisa
Vatamanu, Oana
Giacomini, Maria Eugenia
Campoli, Caterina
Oreni, Letizia
Rizzardini, Giuliano
Viale, Pierluigi
Antinori, Spinello
Giannella, Maddalena
Risk factors associated with bacteremia in COVID-19 patients admitted to intensive care unit: a retrospective multicenter cohort study
title Risk factors associated with bacteremia in COVID-19 patients admitted to intensive care unit: a retrospective multicenter cohort study
title_full Risk factors associated with bacteremia in COVID-19 patients admitted to intensive care unit: a retrospective multicenter cohort study
title_fullStr Risk factors associated with bacteremia in COVID-19 patients admitted to intensive care unit: a retrospective multicenter cohort study
title_full_unstemmed Risk factors associated with bacteremia in COVID-19 patients admitted to intensive care unit: a retrospective multicenter cohort study
title_short Risk factors associated with bacteremia in COVID-19 patients admitted to intensive care unit: a retrospective multicenter cohort study
title_sort risk factors associated with bacteremia in covid-19 patients admitted to intensive care unit: a retrospective multicenter cohort study
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185127/
https://www.ncbi.nlm.nih.gov/pubmed/35687293
http://dx.doi.org/10.1007/s15010-022-01853-4
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