Cargando…

Pattern and Visual Prognostic Factors of Behcet’s Uveitis in Northwest Iran

PURPOSE: To investigate the pattern of ocular involvement in Behcet's disease (BD) with predictors of patients' final state of vision. METHODS: This historical cohort encompassed the clinical records of 200 patients diagnosed according to the International Criteria for BD (ICBD), over a pe...

Descripción completa

Detalles Bibliográficos
Autores principales: Alizadeh Ghavidel, Leila, Bagheri, Masood, Mousavi, Farideh, Rezaei, Leila, Hazeri, Somayyeh, Hashemi, Hesam-Sadat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: PUBLISHED BY KNOWLEDGE E 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185191/
https://www.ncbi.nlm.nih.gov/pubmed/35765637
http://dx.doi.org/10.18502/jovr.v17i2.10796
_version_ 1784724662822895616
author Alizadeh Ghavidel, Leila
Bagheri, Masood
Mousavi, Farideh
Rezaei, Leila
Hazeri, Somayyeh
Hashemi, Hesam-Sadat
author_facet Alizadeh Ghavidel, Leila
Bagheri, Masood
Mousavi, Farideh
Rezaei, Leila
Hazeri, Somayyeh
Hashemi, Hesam-Sadat
author_sort Alizadeh Ghavidel, Leila
collection PubMed
description PURPOSE: To investigate the pattern of ocular involvement in Behcet's disease (BD) with predictors of patients' final state of vision. METHODS: This historical cohort encompassed the clinical records of 200 patients diagnosed according to the International Criteria for BD (ICBD), over a period of 17 years between 2004 and 2021. RESULTS: The prevalence of Behcet's uveitis (BU) was more common in females and patients in the fourth decade of life. Ninety-five patients (47.5%) had evidence of ocular involvement in the initial ophthalmologic evaluation, and 171 patients (85.5%) manifested evidence of BU during the follow-up visits of which bilateral non-granulomatous panuveitis was the most common anatomical pattern of involvement (32.9%) followed by posterior (27.6%), anterior (26.5%), and intermediate (13.8%) uveitis. The prevalent accompanying signs were oral aphthous (67%), skin lesions (29%), and genital ulcers (19.5%). Cystoid macular edema (CME) was the most frequent ocular complication (62%), followed by cataract (57.5%) and epiretinal membranes (ERM) (36.5%). Univariate analysis showed the following determinants: male gender, younger age at onset, panuveitis, posterior uveitis, retinal vasculitis, and longer duration of uveitis as poorer visual prognostic factors of the disease. Multivariate analysis demonstrated a higher chance of poor visual prognosis of BD in patients with panuveitis, posterior uveitis, retinal vasculitis, and longer duration of uveitis. CONCLUSION: This cohort study demonstrated an overview on epidemiological patterns of BU along with the visual prognostic factors in Iranian patients.
format Online
Article
Text
id pubmed-9185191
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher PUBLISHED BY KNOWLEDGE E
record_format MEDLINE/PubMed
spelling pubmed-91851912022-06-27 Pattern and Visual Prognostic Factors of Behcet’s Uveitis in Northwest Iran Alizadeh Ghavidel, Leila Bagheri, Masood Mousavi, Farideh Rezaei, Leila Hazeri, Somayyeh Hashemi, Hesam-Sadat J Ophthalmic Vis Res Original Article PURPOSE: To investigate the pattern of ocular involvement in Behcet's disease (BD) with predictors of patients' final state of vision. METHODS: This historical cohort encompassed the clinical records of 200 patients diagnosed according to the International Criteria for BD (ICBD), over a period of 17 years between 2004 and 2021. RESULTS: The prevalence of Behcet's uveitis (BU) was more common in females and patients in the fourth decade of life. Ninety-five patients (47.5%) had evidence of ocular involvement in the initial ophthalmologic evaluation, and 171 patients (85.5%) manifested evidence of BU during the follow-up visits of which bilateral non-granulomatous panuveitis was the most common anatomical pattern of involvement (32.9%) followed by posterior (27.6%), anterior (26.5%), and intermediate (13.8%) uveitis. The prevalent accompanying signs were oral aphthous (67%), skin lesions (29%), and genital ulcers (19.5%). Cystoid macular edema (CME) was the most frequent ocular complication (62%), followed by cataract (57.5%) and epiretinal membranes (ERM) (36.5%). Univariate analysis showed the following determinants: male gender, younger age at onset, panuveitis, posterior uveitis, retinal vasculitis, and longer duration of uveitis as poorer visual prognostic factors of the disease. Multivariate analysis demonstrated a higher chance of poor visual prognosis of BD in patients with panuveitis, posterior uveitis, retinal vasculitis, and longer duration of uveitis. CONCLUSION: This cohort study demonstrated an overview on epidemiological patterns of BU along with the visual prognostic factors in Iranian patients. PUBLISHED BY KNOWLEDGE E 2022-04-29 /pmc/articles/PMC9185191/ /pubmed/35765637 http://dx.doi.org/10.18502/jovr.v17i2.10796 Text en Copyright © 2022 Ghavidel et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Alizadeh Ghavidel, Leila
Bagheri, Masood
Mousavi, Farideh
Rezaei, Leila
Hazeri, Somayyeh
Hashemi, Hesam-Sadat
Pattern and Visual Prognostic Factors of Behcet’s Uveitis in Northwest Iran
title Pattern and Visual Prognostic Factors of Behcet’s Uveitis in Northwest Iran
title_full Pattern and Visual Prognostic Factors of Behcet’s Uveitis in Northwest Iran
title_fullStr Pattern and Visual Prognostic Factors of Behcet’s Uveitis in Northwest Iran
title_full_unstemmed Pattern and Visual Prognostic Factors of Behcet’s Uveitis in Northwest Iran
title_short Pattern and Visual Prognostic Factors of Behcet’s Uveitis in Northwest Iran
title_sort pattern and visual prognostic factors of behcet’s uveitis in northwest iran
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185191/
https://www.ncbi.nlm.nih.gov/pubmed/35765637
http://dx.doi.org/10.18502/jovr.v17i2.10796
work_keys_str_mv AT alizadehghavidelleila patternandvisualprognosticfactorsofbehcetsuveitisinnorthwestiran
AT bagherimasood patternandvisualprognosticfactorsofbehcetsuveitisinnorthwestiran
AT mousavifarideh patternandvisualprognosticfactorsofbehcetsuveitisinnorthwestiran
AT rezaeileila patternandvisualprognosticfactorsofbehcetsuveitisinnorthwestiran
AT hazerisomayyeh patternandvisualprognosticfactorsofbehcetsuveitisinnorthwestiran
AT hashemihesamsadat patternandvisualprognosticfactorsofbehcetsuveitisinnorthwestiran