Cargando…
Pattern and Visual Prognostic Factors of Behcet’s Uveitis in Northwest Iran
PURPOSE: To investigate the pattern of ocular involvement in Behcet's disease (BD) with predictors of patients' final state of vision. METHODS: This historical cohort encompassed the clinical records of 200 patients diagnosed according to the International Criteria for BD (ICBD), over a pe...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
PUBLISHED BY KNOWLEDGE E
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185191/ https://www.ncbi.nlm.nih.gov/pubmed/35765637 http://dx.doi.org/10.18502/jovr.v17i2.10796 |
_version_ | 1784724662822895616 |
---|---|
author | Alizadeh Ghavidel, Leila Bagheri, Masood Mousavi, Farideh Rezaei, Leila Hazeri, Somayyeh Hashemi, Hesam-Sadat |
author_facet | Alizadeh Ghavidel, Leila Bagheri, Masood Mousavi, Farideh Rezaei, Leila Hazeri, Somayyeh Hashemi, Hesam-Sadat |
author_sort | Alizadeh Ghavidel, Leila |
collection | PubMed |
description | PURPOSE: To investigate the pattern of ocular involvement in Behcet's disease (BD) with predictors of patients' final state of vision. METHODS: This historical cohort encompassed the clinical records of 200 patients diagnosed according to the International Criteria for BD (ICBD), over a period of 17 years between 2004 and 2021. RESULTS: The prevalence of Behcet's uveitis (BU) was more common in females and patients in the fourth decade of life. Ninety-five patients (47.5%) had evidence of ocular involvement in the initial ophthalmologic evaluation, and 171 patients (85.5%) manifested evidence of BU during the follow-up visits of which bilateral non-granulomatous panuveitis was the most common anatomical pattern of involvement (32.9%) followed by posterior (27.6%), anterior (26.5%), and intermediate (13.8%) uveitis. The prevalent accompanying signs were oral aphthous (67%), skin lesions (29%), and genital ulcers (19.5%). Cystoid macular edema (CME) was the most frequent ocular complication (62%), followed by cataract (57.5%) and epiretinal membranes (ERM) (36.5%). Univariate analysis showed the following determinants: male gender, younger age at onset, panuveitis, posterior uveitis, retinal vasculitis, and longer duration of uveitis as poorer visual prognostic factors of the disease. Multivariate analysis demonstrated a higher chance of poor visual prognosis of BD in patients with panuveitis, posterior uveitis, retinal vasculitis, and longer duration of uveitis. CONCLUSION: This cohort study demonstrated an overview on epidemiological patterns of BU along with the visual prognostic factors in Iranian patients. |
format | Online Article Text |
id | pubmed-9185191 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | PUBLISHED BY KNOWLEDGE E |
record_format | MEDLINE/PubMed |
spelling | pubmed-91851912022-06-27 Pattern and Visual Prognostic Factors of Behcet’s Uveitis in Northwest Iran Alizadeh Ghavidel, Leila Bagheri, Masood Mousavi, Farideh Rezaei, Leila Hazeri, Somayyeh Hashemi, Hesam-Sadat J Ophthalmic Vis Res Original Article PURPOSE: To investigate the pattern of ocular involvement in Behcet's disease (BD) with predictors of patients' final state of vision. METHODS: This historical cohort encompassed the clinical records of 200 patients diagnosed according to the International Criteria for BD (ICBD), over a period of 17 years between 2004 and 2021. RESULTS: The prevalence of Behcet's uveitis (BU) was more common in females and patients in the fourth decade of life. Ninety-five patients (47.5%) had evidence of ocular involvement in the initial ophthalmologic evaluation, and 171 patients (85.5%) manifested evidence of BU during the follow-up visits of which bilateral non-granulomatous panuveitis was the most common anatomical pattern of involvement (32.9%) followed by posterior (27.6%), anterior (26.5%), and intermediate (13.8%) uveitis. The prevalent accompanying signs were oral aphthous (67%), skin lesions (29%), and genital ulcers (19.5%). Cystoid macular edema (CME) was the most frequent ocular complication (62%), followed by cataract (57.5%) and epiretinal membranes (ERM) (36.5%). Univariate analysis showed the following determinants: male gender, younger age at onset, panuveitis, posterior uveitis, retinal vasculitis, and longer duration of uveitis as poorer visual prognostic factors of the disease. Multivariate analysis demonstrated a higher chance of poor visual prognosis of BD in patients with panuveitis, posterior uveitis, retinal vasculitis, and longer duration of uveitis. CONCLUSION: This cohort study demonstrated an overview on epidemiological patterns of BU along with the visual prognostic factors in Iranian patients. PUBLISHED BY KNOWLEDGE E 2022-04-29 /pmc/articles/PMC9185191/ /pubmed/35765637 http://dx.doi.org/10.18502/jovr.v17i2.10796 Text en Copyright © 2022 Ghavidel et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Alizadeh Ghavidel, Leila Bagheri, Masood Mousavi, Farideh Rezaei, Leila Hazeri, Somayyeh Hashemi, Hesam-Sadat Pattern and Visual Prognostic Factors of Behcet’s Uveitis in Northwest Iran |
title | Pattern and Visual Prognostic Factors of Behcet’s Uveitis in Northwest Iran |
title_full | Pattern and Visual Prognostic Factors of Behcet’s Uveitis in Northwest Iran |
title_fullStr | Pattern and Visual Prognostic Factors of Behcet’s Uveitis in Northwest Iran |
title_full_unstemmed | Pattern and Visual Prognostic Factors of Behcet’s Uveitis in Northwest Iran |
title_short | Pattern and Visual Prognostic Factors of Behcet’s Uveitis in Northwest Iran |
title_sort | pattern and visual prognostic factors of behcet’s uveitis in northwest iran |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185191/ https://www.ncbi.nlm.nih.gov/pubmed/35765637 http://dx.doi.org/10.18502/jovr.v17i2.10796 |
work_keys_str_mv | AT alizadehghavidelleila patternandvisualprognosticfactorsofbehcetsuveitisinnorthwestiran AT bagherimasood patternandvisualprognosticfactorsofbehcetsuveitisinnorthwestiran AT mousavifarideh patternandvisualprognosticfactorsofbehcetsuveitisinnorthwestiran AT rezaeileila patternandvisualprognosticfactorsofbehcetsuveitisinnorthwestiran AT hazerisomayyeh patternandvisualprognosticfactorsofbehcetsuveitisinnorthwestiran AT hashemihesamsadat patternandvisualprognosticfactorsofbehcetsuveitisinnorthwestiran |