Efficacy and safety of the combined metabolic medication, containing inosine, nicotinamide, riboflavin and succinic acid, for the treatment of diabetic neuropathy: a multicenter randomized, double-blind, placebo-controlled parallel group clinical trial (CYLINDER)

INTRODUCTION: Antioxidants may have positive impact on diabetic polyneuropathy (DPN), presumably due to alleviation of oxidative stress. We aimed to evaluate the efficacy and safety of combination of antioxidants: succinic acid, inosine, nicotinamide, and riboflavin (SINR) in the treatment of DPN. R...

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Detalles Bibliográficos
Autores principales: Kharitonova, Tatiana, Shvarts, Yury G, Verbovoy, Andrey F, Orlova, Natalia S, Puzyreva, Valentina P, Strokov, Igor A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Emerging Technologies, Pharmacology and Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185393/
https://www.ncbi.nlm.nih.gov/pubmed/35680173
http://dx.doi.org/10.1136/bmjdrc-2022-002785

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185393/
https://www.ncbi.nlm.nih.gov/pubmed/35680173
http://dx.doi.org/10.1136/bmjdrc-2022-002785

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