Mechanism Involved in Acute Liver Injury Induced by Intestinal Ischemia-Reperfusion

Intestinal ischemia-reperfusion (I/R) is a common pathophysiological process, which can occur in many conditions such as acute enteric ischemia, severe burns, small intestinal transplantation, etc,. Ischemia-reperfusion of the intestine is often accompanied by distal organ injury, especially liver i...

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Detalles Bibliográficos
Autores principales: Jin, Binghui, Li, Guangyao, Zhou, Lin, Fan, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185410/
https://www.ncbi.nlm.nih.gov/pubmed/35694264
http://dx.doi.org/10.3389/fphar.2022.924695
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author Jin, Binghui
Li, Guangyao
Zhou, Lin
Fan, Zhe
author_facet Jin, Binghui
Li, Guangyao
Zhou, Lin
Fan, Zhe
author_sort Jin, Binghui
collection PubMed
description Intestinal ischemia-reperfusion (I/R) is a common pathophysiological process, which can occur in many conditions such as acute enteric ischemia, severe burns, small intestinal transplantation, etc,. Ischemia-reperfusion of the intestine is often accompanied by distal organ injury, especially liver injury. This paper outlined the signal pathways and cytokines involved in acute liver injury induced by intestinal I/R: the NF-κB Signaling Pathway, the P66shc Signaling Pathway, the HMGB1 Signaling Pathway, the Nrf2-ARE Signaling Pathway, the AMPK-SIRT-1 Signaling Pathway and other cytokines, providing new ideas for the prevention and treatment of liver injury caused by reperfusion after intestinal I/R.
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spelling pubmed-91854102022-06-11 Mechanism Involved in Acute Liver Injury Induced by Intestinal Ischemia-Reperfusion Jin, Binghui Li, Guangyao Zhou, Lin Fan, Zhe Front Pharmacol Pharmacology Intestinal ischemia-reperfusion (I/R) is a common pathophysiological process, which can occur in many conditions such as acute enteric ischemia, severe burns, small intestinal transplantation, etc,. Ischemia-reperfusion of the intestine is often accompanied by distal organ injury, especially liver injury. This paper outlined the signal pathways and cytokines involved in acute liver injury induced by intestinal I/R: the NF-κB Signaling Pathway, the P66shc Signaling Pathway, the HMGB1 Signaling Pathway, the Nrf2-ARE Signaling Pathway, the AMPK-SIRT-1 Signaling Pathway and other cytokines, providing new ideas for the prevention and treatment of liver injury caused by reperfusion after intestinal I/R. Frontiers Media S.A. 2022-05-23 /pmc/articles/PMC9185410/ /pubmed/35694264 http://dx.doi.org/10.3389/fphar.2022.924695 Text en Copyright © 2022 Jin, Li, Zhou and Fan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Jin, Binghui
Li, Guangyao
Zhou, Lin
Fan, Zhe
Mechanism Involved in Acute Liver Injury Induced by Intestinal Ischemia-Reperfusion
title Mechanism Involved in Acute Liver Injury Induced by Intestinal Ischemia-Reperfusion
title_full Mechanism Involved in Acute Liver Injury Induced by Intestinal Ischemia-Reperfusion
title_fullStr Mechanism Involved in Acute Liver Injury Induced by Intestinal Ischemia-Reperfusion
title_full_unstemmed Mechanism Involved in Acute Liver Injury Induced by Intestinal Ischemia-Reperfusion
title_short Mechanism Involved in Acute Liver Injury Induced by Intestinal Ischemia-Reperfusion
title_sort mechanism involved in acute liver injury induced by intestinal ischemia-reperfusion
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185410/
https://www.ncbi.nlm.nih.gov/pubmed/35694264
http://dx.doi.org/10.3389/fphar.2022.924695
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AT zhoulin mechanisminvolvedinacuteliverinjuryinducedbyintestinalischemiareperfusion
AT fanzhe mechanisminvolvedinacuteliverinjuryinducedbyintestinalischemiareperfusion

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