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Developmental Self-Assembly of a DNA Ring with Stimulus-Responsive Size and Growth Direction

[Image: see text] Developmental self-assembly of DNA nanostructures provides an ideal platform for studying the power and programmability of kinetically controlled structural growth in engineered molecular systems. Triggered initiation and designated sequencing of assembly and disassembly steps have...

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Autores principales: Glynn, Allison T., Davidson, Samuel R., Qian, Lulu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185747/
https://www.ncbi.nlm.nih.gov/pubmed/35617523
http://dx.doi.org/10.1021/jacs.2c03853
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author Glynn, Allison T.
Davidson, Samuel R.
Qian, Lulu
author_facet Glynn, Allison T.
Davidson, Samuel R.
Qian, Lulu
author_sort Glynn, Allison T.
collection PubMed
description [Image: see text] Developmental self-assembly of DNA nanostructures provides an ideal platform for studying the power and programmability of kinetically controlled structural growth in engineered molecular systems. Triggered initiation and designated sequencing of assembly and disassembly steps have been demonstrated in structures with branches and loops. Here we introduce a new strategy for selectively activating distinct subroutines in a developmental self-assembly program, allowing structures with distinct properties to be created in response to various molecular signals. We demonstrate this strategy in triggered self-assembly of a DNA ring, the size and growth direction of which are responsive to a key molecule. We articulate that reversible assembly steps with slow kinetics at appropriate locations in a reaction pathway could enable multiple populations of structures with stimulus-responsive properties to be simultaneously created in one developmental program. These results open up a broad design space for the self-assembly of molecules with adaptive behaviors toward advanced control in synthetic materials and molecular motors.
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spelling pubmed-91857472022-06-11 Developmental Self-Assembly of a DNA Ring with Stimulus-Responsive Size and Growth Direction Glynn, Allison T. Davidson, Samuel R. Qian, Lulu J Am Chem Soc [Image: see text] Developmental self-assembly of DNA nanostructures provides an ideal platform for studying the power and programmability of kinetically controlled structural growth in engineered molecular systems. Triggered initiation and designated sequencing of assembly and disassembly steps have been demonstrated in structures with branches and loops. Here we introduce a new strategy for selectively activating distinct subroutines in a developmental self-assembly program, allowing structures with distinct properties to be created in response to various molecular signals. We demonstrate this strategy in triggered self-assembly of a DNA ring, the size and growth direction of which are responsive to a key molecule. We articulate that reversible assembly steps with slow kinetics at appropriate locations in a reaction pathway could enable multiple populations of structures with stimulus-responsive properties to be simultaneously created in one developmental program. These results open up a broad design space for the self-assembly of molecules with adaptive behaviors toward advanced control in synthetic materials and molecular motors. American Chemical Society 2022-05-26 2022-06-08 /pmc/articles/PMC9185747/ /pubmed/35617523 http://dx.doi.org/10.1021/jacs.2c03853 Text en © 2022 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by-nc-nd/4.0/Permits non-commercial access and re-use, provided that author attribution and integrity are maintained; but does not permit creation of adaptations or other derivative works (https://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Glynn, Allison T.
Davidson, Samuel R.
Qian, Lulu
Developmental Self-Assembly of a DNA Ring with Stimulus-Responsive Size and Growth Direction
title Developmental Self-Assembly of a DNA Ring with Stimulus-Responsive Size and Growth Direction
title_full Developmental Self-Assembly of a DNA Ring with Stimulus-Responsive Size and Growth Direction
title_fullStr Developmental Self-Assembly of a DNA Ring with Stimulus-Responsive Size and Growth Direction
title_full_unstemmed Developmental Self-Assembly of a DNA Ring with Stimulus-Responsive Size and Growth Direction
title_short Developmental Self-Assembly of a DNA Ring with Stimulus-Responsive Size and Growth Direction
title_sort developmental self-assembly of a dna ring with stimulus-responsive size and growth direction
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185747/
https://www.ncbi.nlm.nih.gov/pubmed/35617523
http://dx.doi.org/10.1021/jacs.2c03853
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