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Depression: An Insight into Heterocyclic and Cyclic Hydrocarbon Compounds Inspired from Natural Sources

Depression, a well-known mental disorder, has global prevalence, affecting nearly 17% of the population. Due to various limitations of the currently available drugs, people have been adopting traditional herbal medicines to alleviate the symptoms of depression. It is notable to mention that natural...

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Autores principales: Shah, Abdul Jalil, Mir, Reyaz Hassan, Pottoo, Faheem Hyder, Masoodi, Mubashir Hussain, Bhat, Zulfiqar Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185790/
https://www.ncbi.nlm.nih.gov/pubmed/33902421
http://dx.doi.org/10.2174/1570159X19666210426115234
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author Shah, Abdul Jalil
Mir, Reyaz Hassan
Pottoo, Faheem Hyder
Masoodi, Mubashir Hussain
Bhat, Zulfiqar Ali
author_facet Shah, Abdul Jalil
Mir, Reyaz Hassan
Pottoo, Faheem Hyder
Masoodi, Mubashir Hussain
Bhat, Zulfiqar Ali
author_sort Shah, Abdul Jalil
collection PubMed
description Depression, a well-known mental disorder, has global prevalence, affecting nearly 17% of the population. Due to various limitations of the currently available drugs, people have been adopting traditional herbal medicines to alleviate the symptoms of depression. It is notable to mention that natural products, their derivatives, and their analogs are the main sources for new drug candidates of depression. The mechanisms include interplay with γ-aminobutyric acid (GABA) receptors, serotonergic, dopaminergic noradrenergic systems, and elevation of BDNF levels. The focus of this article is to review the role of signalling molecules in depression and highlight the use of plant-derived natural compounds to counter CNS depression.
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spelling pubmed-91857902022-06-27 Depression: An Insight into Heterocyclic and Cyclic Hydrocarbon Compounds Inspired from Natural Sources Shah, Abdul Jalil Mir, Reyaz Hassan Pottoo, Faheem Hyder Masoodi, Mubashir Hussain Bhat, Zulfiqar Ali Curr Neuropharmacol Article Depression, a well-known mental disorder, has global prevalence, affecting nearly 17% of the population. Due to various limitations of the currently available drugs, people have been adopting traditional herbal medicines to alleviate the symptoms of depression. It is notable to mention that natural products, their derivatives, and their analogs are the main sources for new drug candidates of depression. The mechanisms include interplay with γ-aminobutyric acid (GABA) receptors, serotonergic, dopaminergic noradrenergic systems, and elevation of BDNF levels. The focus of this article is to review the role of signalling molecules in depression and highlight the use of plant-derived natural compounds to counter CNS depression. Bentham Science Publishers 2021-11-15 2021-11-15 /pmc/articles/PMC9185790/ /pubmed/33902421 http://dx.doi.org/10.2174/1570159X19666210426115234 Text en © 2021 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Shah, Abdul Jalil
Mir, Reyaz Hassan
Pottoo, Faheem Hyder
Masoodi, Mubashir Hussain
Bhat, Zulfiqar Ali
Depression: An Insight into Heterocyclic and Cyclic Hydrocarbon Compounds Inspired from Natural Sources
title Depression: An Insight into Heterocyclic and Cyclic Hydrocarbon Compounds Inspired from Natural Sources
title_full Depression: An Insight into Heterocyclic and Cyclic Hydrocarbon Compounds Inspired from Natural Sources
title_fullStr Depression: An Insight into Heterocyclic and Cyclic Hydrocarbon Compounds Inspired from Natural Sources
title_full_unstemmed Depression: An Insight into Heterocyclic and Cyclic Hydrocarbon Compounds Inspired from Natural Sources
title_short Depression: An Insight into Heterocyclic and Cyclic Hydrocarbon Compounds Inspired from Natural Sources
title_sort depression: an insight into heterocyclic and cyclic hydrocarbon compounds inspired from natural sources
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185790/
https://www.ncbi.nlm.nih.gov/pubmed/33902421
http://dx.doi.org/10.2174/1570159X19666210426115234
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