Implications of regulator of G-protein signaling 5 expression in the pathogenesis of primary and secondary hyperparathyroidism

OBJECTIVE: To study the protein and mRNA expressions of regulator of G-protein signaling 5 (RGS5) in the pathogenesis of hyperparathyroidism. METHODS: The expression of RGS5 protein in 20 primary hyperparathyroidism (PHPT), 31 secondary hyperparathyroidism (SHPT), and 20 control cases were studied b...

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Detalles Bibliográficos
Autores principales: Li, Xin, Lu, Yao, Zhang, Ling, Song, Aiping, Zhang, Honglei, Pang, Bo, Liu, Jun, Sun, Xiaoliang, Ji, Haoyang, Huang, Linping, Yang, Meng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185949/
https://www.ncbi.nlm.nih.gov/pubmed/35681135
http://dx.doi.org/10.1186/s12902-022-01066-8
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author Li, Xin
Lu, Yao
Zhang, Ling
Song, Aiping
Zhang, Honglei
Pang, Bo
Liu, Jun
Sun, Xiaoliang
Ji, Haoyang
Huang, Linping
Yang, Meng
author_facet Li, Xin
Lu, Yao
Zhang, Ling
Song, Aiping
Zhang, Honglei
Pang, Bo
Liu, Jun
Sun, Xiaoliang
Ji, Haoyang
Huang, Linping
Yang, Meng
author_sort Li, Xin
collection PubMed
description OBJECTIVE: To study the protein and mRNA expressions of regulator of G-protein signaling 5 (RGS5) in the pathogenesis of hyperparathyroidism. METHODS: The expression of RGS5 protein in 20 primary hyperparathyroidism (PHPT), 31 secondary hyperparathyroidism (SHPT), and 20 control cases were studied by immunohistochemistry (IHC). The expression of RGS5 mRNA in 15 PHPT, 102 SHPT, and 7 normal parathyroid tissue were measured by quantitative real-time PCR (qRT-PCR) method. RESULTS: The expressions of RGS5 in PHPT tissues were significantly higher than that in SHPT and normal parathyroid tissues (P < 0.05). While the differences in RGS5 protein expressions between SHPT and respective control samples were not statistically significant (P > 0.05). Likewise, the RGS5 mRNA expression in PHPT was significantly higher than that in SHPT (P < 0.05) and normal parathyroid (P < 0.05) samples. In a similar line, the differences in RGS5 gene expressions between SHPT and control tissues were not statistically significant (P > 0.05). CONCLUSIONS: The characteristic RGS5 protein and mRNA levels in hyperparathyroidism might be helpful in discovering the pathomechanism of hyperparathyroidism and novel therapeutic targets as well.
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spelling pubmed-91859492022-06-11 Implications of regulator of G-protein signaling 5 expression in the pathogenesis of primary and secondary hyperparathyroidism Li, Xin Lu, Yao Zhang, Ling Song, Aiping Zhang, Honglei Pang, Bo Liu, Jun Sun, Xiaoliang Ji, Haoyang Huang, Linping Yang, Meng BMC Endocr Disord Research OBJECTIVE: To study the protein and mRNA expressions of regulator of G-protein signaling 5 (RGS5) in the pathogenesis of hyperparathyroidism. METHODS: The expression of RGS5 protein in 20 primary hyperparathyroidism (PHPT), 31 secondary hyperparathyroidism (SHPT), and 20 control cases were studied by immunohistochemistry (IHC). The expression of RGS5 mRNA in 15 PHPT, 102 SHPT, and 7 normal parathyroid tissue were measured by quantitative real-time PCR (qRT-PCR) method. RESULTS: The expressions of RGS5 in PHPT tissues were significantly higher than that in SHPT and normal parathyroid tissues (P < 0.05). While the differences in RGS5 protein expressions between SHPT and respective control samples were not statistically significant (P > 0.05). Likewise, the RGS5 mRNA expression in PHPT was significantly higher than that in SHPT (P < 0.05) and normal parathyroid (P < 0.05) samples. In a similar line, the differences in RGS5 gene expressions between SHPT and control tissues were not statistically significant (P > 0.05). CONCLUSIONS: The characteristic RGS5 protein and mRNA levels in hyperparathyroidism might be helpful in discovering the pathomechanism of hyperparathyroidism and novel therapeutic targets as well. BioMed Central 2022-06-09 /pmc/articles/PMC9185949/ /pubmed/35681135 http://dx.doi.org/10.1186/s12902-022-01066-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Li, Xin
Lu, Yao
Zhang, Ling
Song, Aiping
Zhang, Honglei
Pang, Bo
Liu, Jun
Sun, Xiaoliang
Ji, Haoyang
Huang, Linping
Yang, Meng
Implications of regulator of G-protein signaling 5 expression in the pathogenesis of primary and secondary hyperparathyroidism
title Implications of regulator of G-protein signaling 5 expression in the pathogenesis of primary and secondary hyperparathyroidism
title_full Implications of regulator of G-protein signaling 5 expression in the pathogenesis of primary and secondary hyperparathyroidism
title_fullStr Implications of regulator of G-protein signaling 5 expression in the pathogenesis of primary and secondary hyperparathyroidism
title_full_unstemmed Implications of regulator of G-protein signaling 5 expression in the pathogenesis of primary and secondary hyperparathyroidism
title_short Implications of regulator of G-protein signaling 5 expression in the pathogenesis of primary and secondary hyperparathyroidism
title_sort implications of regulator of g-protein signaling 5 expression in the pathogenesis of primary and secondary hyperparathyroidism
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185949/
https://www.ncbi.nlm.nih.gov/pubmed/35681135
http://dx.doi.org/10.1186/s12902-022-01066-8
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