Evaluation of short-term epigenetic age fluctuation

Considerable effort has been spent on lowering and maintaining the epigenetic age. However, the extent to which epigenetic age fluctuates under normal conditions is poorly understood. Therefore, we analyzed methylation data from monocytes and peripheral blood mononuclear cells collected from two Jap...

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Autores principales: Komaki, Shohei, Ohmomo, Hideki, Hachiya, Tsuyoshi, Sutoh, Yoichi, Ono, Kanako, Furukawa, Ryohei, Umekage, So, Otsuka-Yamasaki, Yayoi, Minabe, Shiori, Takashima, Akira, Tanno, Kozo, Sasaki, Makoto, Shimizu, Atsushi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185970/
https://www.ncbi.nlm.nih.gov/pubmed/35681206
http://dx.doi.org/10.1186/s13148-022-01293-9
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author Komaki, Shohei
Ohmomo, Hideki
Hachiya, Tsuyoshi
Sutoh, Yoichi
Ono, Kanako
Furukawa, Ryohei
Umekage, So
Otsuka-Yamasaki, Yayoi
Minabe, Shiori
Takashima, Akira
Tanno, Kozo
Sasaki, Makoto
Shimizu, Atsushi
author_facet Komaki, Shohei
Ohmomo, Hideki
Hachiya, Tsuyoshi
Sutoh, Yoichi
Ono, Kanako
Furukawa, Ryohei
Umekage, So
Otsuka-Yamasaki, Yayoi
Minabe, Shiori
Takashima, Akira
Tanno, Kozo
Sasaki, Makoto
Shimizu, Atsushi
author_sort Komaki, Shohei
collection PubMed
description Considerable effort has been spent on lowering and maintaining the epigenetic age. However, the extent to which epigenetic age fluctuates under normal conditions is poorly understood. Therefore, we analyzed methylation data from monocytes and peripheral blood mononuclear cells collected from two Japanese men. The ranges of the Pan-tissue, Skin and blood, and DNAm PhenoAge epigenetic age during 3 months were ≥ 5.62, ≥ 3.04, and ≥ 8.23 years, and the maximum daily changes were 5.21, 3.20, and 6.53 years, respectively. These fluctuations were not suppressed by correcting for cell-type composition. Although the underlying biological mechanism remains unclear, there was a nonnegligible degree of age fluctuation which should inform personalized clinical applications. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13148-022-01293-9.
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spelling pubmed-91859702022-06-11 Evaluation of short-term epigenetic age fluctuation Komaki, Shohei Ohmomo, Hideki Hachiya, Tsuyoshi Sutoh, Yoichi Ono, Kanako Furukawa, Ryohei Umekage, So Otsuka-Yamasaki, Yayoi Minabe, Shiori Takashima, Akira Tanno, Kozo Sasaki, Makoto Shimizu, Atsushi Clin Epigenetics Brief Report Considerable effort has been spent on lowering and maintaining the epigenetic age. However, the extent to which epigenetic age fluctuates under normal conditions is poorly understood. Therefore, we analyzed methylation data from monocytes and peripheral blood mononuclear cells collected from two Japanese men. The ranges of the Pan-tissue, Skin and blood, and DNAm PhenoAge epigenetic age during 3 months were ≥ 5.62, ≥ 3.04, and ≥ 8.23 years, and the maximum daily changes were 5.21, 3.20, and 6.53 years, respectively. These fluctuations were not suppressed by correcting for cell-type composition. Although the underlying biological mechanism remains unclear, there was a nonnegligible degree of age fluctuation which should inform personalized clinical applications. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13148-022-01293-9. BioMed Central 2022-06-09 /pmc/articles/PMC9185970/ /pubmed/35681206 http://dx.doi.org/10.1186/s13148-022-01293-9 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Brief Report
Komaki, Shohei
Ohmomo, Hideki
Hachiya, Tsuyoshi
Sutoh, Yoichi
Ono, Kanako
Furukawa, Ryohei
Umekage, So
Otsuka-Yamasaki, Yayoi
Minabe, Shiori
Takashima, Akira
Tanno, Kozo
Sasaki, Makoto
Shimizu, Atsushi
Evaluation of short-term epigenetic age fluctuation
title Evaluation of short-term epigenetic age fluctuation
title_full Evaluation of short-term epigenetic age fluctuation
title_fullStr Evaluation of short-term epigenetic age fluctuation
title_full_unstemmed Evaluation of short-term epigenetic age fluctuation
title_short Evaluation of short-term epigenetic age fluctuation
title_sort evaluation of short-term epigenetic age fluctuation
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185970/
https://www.ncbi.nlm.nih.gov/pubmed/35681206
http://dx.doi.org/10.1186/s13148-022-01293-9
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