Cargando…
SRF: a seriously responsible factor in cardiac development and disease
The molecular mechanisms that regulate embryogenesis and cardiac development are calibrated by multiple signal transduction pathways within or between different cell lineages via autocrine or paracrine mechanisms of action. The heart is the first functional organ to form during development, which hi...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185982/ https://www.ncbi.nlm.nih.gov/pubmed/35681202 http://dx.doi.org/10.1186/s12929-022-00820-3 |
_version_ | 1784724840627830784 |
---|---|
author | Deshpande, Anushka Shetty, Prithviraj Manohar Vijaya Frey, Norbert Rangrez, Ashraf Yusuf |
author_facet | Deshpande, Anushka Shetty, Prithviraj Manohar Vijaya Frey, Norbert Rangrez, Ashraf Yusuf |
author_sort | Deshpande, Anushka |
collection | PubMed |
description | The molecular mechanisms that regulate embryogenesis and cardiac development are calibrated by multiple signal transduction pathways within or between different cell lineages via autocrine or paracrine mechanisms of action. The heart is the first functional organ to form during development, which highlights the importance of this organ in later stages of growth. Knowledge of the regulatory mechanisms underlying cardiac development and adult cardiac homeostasis paves the way for discovering therapeutic possibilities for cardiac disease treatment. Serum response factor (SRF) is a major transcription factor that controls both embryonic and adult cardiac development. SRF expression is needed through the duration of development, from the first mesodermal cell in a developing embryo to the last cell damaged by infarction in the myocardium. Precise regulation of SRF expression is critical for mesoderm formation and cardiac crescent formation in the embryo, and altered SRF levels lead to cardiomyopathies in the adult heart, suggesting the vital role played by SRF in cardiac development and disease. This review provides a detailed overview of SRF and its partners in their various functions and discusses the future scope and possible therapeutic potential of SRF in the cardiovascular system. |
format | Online Article Text |
id | pubmed-9185982 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-91859822022-06-11 SRF: a seriously responsible factor in cardiac development and disease Deshpande, Anushka Shetty, Prithviraj Manohar Vijaya Frey, Norbert Rangrez, Ashraf Yusuf J Biomed Sci Review The molecular mechanisms that regulate embryogenesis and cardiac development are calibrated by multiple signal transduction pathways within or between different cell lineages via autocrine or paracrine mechanisms of action. The heart is the first functional organ to form during development, which highlights the importance of this organ in later stages of growth. Knowledge of the regulatory mechanisms underlying cardiac development and adult cardiac homeostasis paves the way for discovering therapeutic possibilities for cardiac disease treatment. Serum response factor (SRF) is a major transcription factor that controls both embryonic and adult cardiac development. SRF expression is needed through the duration of development, from the first mesodermal cell in a developing embryo to the last cell damaged by infarction in the myocardium. Precise regulation of SRF expression is critical for mesoderm formation and cardiac crescent formation in the embryo, and altered SRF levels lead to cardiomyopathies in the adult heart, suggesting the vital role played by SRF in cardiac development and disease. This review provides a detailed overview of SRF and its partners in their various functions and discusses the future scope and possible therapeutic potential of SRF in the cardiovascular system. BioMed Central 2022-06-09 /pmc/articles/PMC9185982/ /pubmed/35681202 http://dx.doi.org/10.1186/s12929-022-00820-3 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Review Deshpande, Anushka Shetty, Prithviraj Manohar Vijaya Frey, Norbert Rangrez, Ashraf Yusuf SRF: a seriously responsible factor in cardiac development and disease |
title | SRF: a seriously responsible factor in cardiac development and disease |
title_full | SRF: a seriously responsible factor in cardiac development and disease |
title_fullStr | SRF: a seriously responsible factor in cardiac development and disease |
title_full_unstemmed | SRF: a seriously responsible factor in cardiac development and disease |
title_short | SRF: a seriously responsible factor in cardiac development and disease |
title_sort | srf: a seriously responsible factor in cardiac development and disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9185982/ https://www.ncbi.nlm.nih.gov/pubmed/35681202 http://dx.doi.org/10.1186/s12929-022-00820-3 |
work_keys_str_mv | AT deshpandeanushka srfaseriouslyresponsiblefactorincardiacdevelopmentanddisease AT shettyprithvirajmanoharvijaya srfaseriouslyresponsiblefactorincardiacdevelopmentanddisease AT freynorbert srfaseriouslyresponsiblefactorincardiacdevelopmentanddisease AT rangrezashrafyusuf srfaseriouslyresponsiblefactorincardiacdevelopmentanddisease |