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EEG Signals Index a Global Signature of Arousal Embedded in Neuronal Population Recordings

Electroencephalography (EEG) has long been used to index brain states, from early studies describing activity in the presence and absence of visual stimulation to modern work employing complex perceptual tasks. These studies have shed light on brain-wide signals but often lack explanatory power at t...

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Detalles Bibliográficos
Autores principales: Johnston, Richard, Snyder, Adam C., Schibler, Rachel S., Smith, Matthew A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society for Neuroscience 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186107/
https://www.ncbi.nlm.nih.gov/pubmed/35606150
http://dx.doi.org/10.1523/ENEURO.0012-22.2022
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author Johnston, Richard
Snyder, Adam C.
Schibler, Rachel S.
Smith, Matthew A.
author_facet Johnston, Richard
Snyder, Adam C.
Schibler, Rachel S.
Smith, Matthew A.
author_sort Johnston, Richard
collection PubMed
description Electroencephalography (EEG) has long been used to index brain states, from early studies describing activity in the presence and absence of visual stimulation to modern work employing complex perceptual tasks. These studies have shed light on brain-wide signals but often lack explanatory power at the single neuron level. Similarly, single neuron recordings can suffer from an inability to measure brain-wide signals accessible using EEG. Here, we combined these techniques while monkeys performed a change detection task and discovered a novel link between spontaneous EEG activity and a neural signal embedded in the spiking responses of neuronal populations. This “slow drift” was associated with fluctuations in the subjects’ arousal levels over time: decreases in prestimulus α power were accompanied by increases in pupil size and decreases in microsaccade rate. These results show that brain-wide EEG signals can be used to index modes of activity present in single neuron recordings, that in turn reflect global changes in brain state that influence perception and behavior.
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spelling pubmed-91861072022-06-13 EEG Signals Index a Global Signature of Arousal Embedded in Neuronal Population Recordings Johnston, Richard Snyder, Adam C. Schibler, Rachel S. Smith, Matthew A. eNeuro Research Article: New Research Electroencephalography (EEG) has long been used to index brain states, from early studies describing activity in the presence and absence of visual stimulation to modern work employing complex perceptual tasks. These studies have shed light on brain-wide signals but often lack explanatory power at the single neuron level. Similarly, single neuron recordings can suffer from an inability to measure brain-wide signals accessible using EEG. Here, we combined these techniques while monkeys performed a change detection task and discovered a novel link between spontaneous EEG activity and a neural signal embedded in the spiking responses of neuronal populations. This “slow drift” was associated with fluctuations in the subjects’ arousal levels over time: decreases in prestimulus α power were accompanied by increases in pupil size and decreases in microsaccade rate. These results show that brain-wide EEG signals can be used to index modes of activity present in single neuron recordings, that in turn reflect global changes in brain state that influence perception and behavior. Society for Neuroscience 2022-06-07 /pmc/articles/PMC9186107/ /pubmed/35606150 http://dx.doi.org/10.1523/ENEURO.0012-22.2022 Text en Copyright © 2022 Johnston et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.
spellingShingle Research Article: New Research
Johnston, Richard
Snyder, Adam C.
Schibler, Rachel S.
Smith, Matthew A.
EEG Signals Index a Global Signature of Arousal Embedded in Neuronal Population Recordings
title EEG Signals Index a Global Signature of Arousal Embedded in Neuronal Population Recordings
title_full EEG Signals Index a Global Signature of Arousal Embedded in Neuronal Population Recordings
title_fullStr EEG Signals Index a Global Signature of Arousal Embedded in Neuronal Population Recordings
title_full_unstemmed EEG Signals Index a Global Signature of Arousal Embedded in Neuronal Population Recordings
title_short EEG Signals Index a Global Signature of Arousal Embedded in Neuronal Population Recordings
title_sort eeg signals index a global signature of arousal embedded in neuronal population recordings
topic Research Article: New Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186107/
https://www.ncbi.nlm.nih.gov/pubmed/35606150
http://dx.doi.org/10.1523/ENEURO.0012-22.2022
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