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Sequence-based modeling of three-dimensional genome architecture from kilobase to chromosome scale
To learn how genomic sequence influences multiscale three-dimensional (3D) genome architecture, this manuscript presents a sequence-based deep learning approach, Orca, that predicts directly from sequence the 3D genome architecture from kilobase to whole-chromosome scale. Orca captures the sequence...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186125/ https://www.ncbi.nlm.nih.gov/pubmed/35551308 http://dx.doi.org/10.1038/s41588-022-01065-4 |