Axonal injury in asymptomatic individuals preceding onset of multiple sclerosis

Axonal loss is the main cause of irreversible disability in multiple sclerosis (MS). Serum neurofilament light (sNfL) is a biomarker of axonal disintegration. In this nested case–control study, blood samples from 519 presymptomatic persons (age range 4–39 years) who later received an MS diagnosis sh...

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Autores principales: Jons, Daniel, Zetterberg, Henrik, Biström, Martin, Alonso‐Magdalena, Lucia, Gunnarsson, Martin, Vrethem, Magnus, Blennow, Kaj, Nilsson, Staffan, Sundström, Peter, Andersen, Oluf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186135/
https://www.ncbi.nlm.nih.gov/pubmed/35502756
http://dx.doi.org/10.1002/acn3.51568
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author Jons, Daniel
Zetterberg, Henrik
Biström, Martin
Alonso‐Magdalena, Lucia
Gunnarsson, Martin
Vrethem, Magnus
Blennow, Kaj
Nilsson, Staffan
Sundström, Peter
Andersen, Oluf
author_facet Jons, Daniel
Zetterberg, Henrik
Biström, Martin
Alonso‐Magdalena, Lucia
Gunnarsson, Martin
Vrethem, Magnus
Blennow, Kaj
Nilsson, Staffan
Sundström, Peter
Andersen, Oluf
author_sort Jons, Daniel
collection PubMed
description Axonal loss is the main cause of irreversible disability in multiple sclerosis (MS). Serum neurofilament light (sNfL) is a biomarker of axonal disintegration. In this nested case–control study, blood samples from 519 presymptomatic persons (age range 4–39 years) who later received an MS diagnosis showed higher sNfL concentrations than 519 matched controls (p < 0.0001), noticeable at least 10 years before clinical MS onset. Mean values for pre‐MS and control groups were 9.6 pg/mL versus 7.4 pg/mL 0–5 years before onset, and 6.4 pg/mL versus 5.8 pg/mL 5–10 years before onset. These results support that axonal injury occurs early in MS pathogenesis.
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spelling pubmed-91861352022-06-14 Axonal injury in asymptomatic individuals preceding onset of multiple sclerosis Jons, Daniel Zetterberg, Henrik Biström, Martin Alonso‐Magdalena, Lucia Gunnarsson, Martin Vrethem, Magnus Blennow, Kaj Nilsson, Staffan Sundström, Peter Andersen, Oluf Ann Clin Transl Neurol Brief Communications Axonal loss is the main cause of irreversible disability in multiple sclerosis (MS). Serum neurofilament light (sNfL) is a biomarker of axonal disintegration. In this nested case–control study, blood samples from 519 presymptomatic persons (age range 4–39 years) who later received an MS diagnosis showed higher sNfL concentrations than 519 matched controls (p < 0.0001), noticeable at least 10 years before clinical MS onset. Mean values for pre‐MS and control groups were 9.6 pg/mL versus 7.4 pg/mL 0–5 years before onset, and 6.4 pg/mL versus 5.8 pg/mL 5–10 years before onset. These results support that axonal injury occurs early in MS pathogenesis. John Wiley and Sons Inc. 2022-05-03 /pmc/articles/PMC9186135/ /pubmed/35502756 http://dx.doi.org/10.1002/acn3.51568 Text en © 2022 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals LLC on behalf of American Neurological Association. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communications
Jons, Daniel
Zetterberg, Henrik
Biström, Martin
Alonso‐Magdalena, Lucia
Gunnarsson, Martin
Vrethem, Magnus
Blennow, Kaj
Nilsson, Staffan
Sundström, Peter
Andersen, Oluf
Axonal injury in asymptomatic individuals preceding onset of multiple sclerosis
title Axonal injury in asymptomatic individuals preceding onset of multiple sclerosis
title_full Axonal injury in asymptomatic individuals preceding onset of multiple sclerosis
title_fullStr Axonal injury in asymptomatic individuals preceding onset of multiple sclerosis
title_full_unstemmed Axonal injury in asymptomatic individuals preceding onset of multiple sclerosis
title_short Axonal injury in asymptomatic individuals preceding onset of multiple sclerosis
title_sort axonal injury in asymptomatic individuals preceding onset of multiple sclerosis
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186135/
https://www.ncbi.nlm.nih.gov/pubmed/35502756
http://dx.doi.org/10.1002/acn3.51568
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