From Insect Bites to a Skin Autoimmune Disease: A Conceivable Pathway to Endemic Pemphigus Foliaceus

In the endemic variants of pemphigus foliaceus (PF), in Brazil and Tunisia, patients generate pathogenic IgG4 anti-desmoglein 1 autoantibodies. Additionally, these patients possess antibodies against salivary proteins from sand flies that react with Dsg1, which may lead to skin disease in susceptibl...

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Autores principales: Li, Ning, Aoki, Valeria, Liu, Zhi, Prisayanh, Phillip, Valenzuela, Jesus G., Diaz, Luis A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186141/
https://www.ncbi.nlm.nih.gov/pubmed/35693761
http://dx.doi.org/10.3389/fimmu.2022.907424
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author Li, Ning
Aoki, Valeria
Liu, Zhi
Prisayanh, Phillip
Valenzuela, Jesus G.
Diaz, Luis A.
author_facet Li, Ning
Aoki, Valeria
Liu, Zhi
Prisayanh, Phillip
Valenzuela, Jesus G.
Diaz, Luis A.
author_sort Li, Ning
collection PubMed
description In the endemic variants of pemphigus foliaceus (PF), in Brazil and Tunisia, patients generate pathogenic IgG4 anti-desmoglein 1 autoantibodies. Additionally, these patients possess antibodies against salivary proteins from sand flies that react with Dsg1, which may lead to skin disease in susceptible individuals living in endemic areas. This minireview focuses on recent studies highlighting the possible role of salivary proteins from Lutzomyia longipalpis (L. longipalpis) in EPF from Brazil and Phlebotomus papatasi (P. papatasi) in EPF from Tunisia. We will briefly discuss the potential mechanisms of molecular mimicry and epitope spreading in the initiation and development of endemic PF (EPF) in Brazil and Tunisia.
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spelling pubmed-91861412022-06-11 From Insect Bites to a Skin Autoimmune Disease: A Conceivable Pathway to Endemic Pemphigus Foliaceus Li, Ning Aoki, Valeria Liu, Zhi Prisayanh, Phillip Valenzuela, Jesus G. Diaz, Luis A. Front Immunol Immunology In the endemic variants of pemphigus foliaceus (PF), in Brazil and Tunisia, patients generate pathogenic IgG4 anti-desmoglein 1 autoantibodies. Additionally, these patients possess antibodies against salivary proteins from sand flies that react with Dsg1, which may lead to skin disease in susceptible individuals living in endemic areas. This minireview focuses on recent studies highlighting the possible role of salivary proteins from Lutzomyia longipalpis (L. longipalpis) in EPF from Brazil and Phlebotomus papatasi (P. papatasi) in EPF from Tunisia. We will briefly discuss the potential mechanisms of molecular mimicry and epitope spreading in the initiation and development of endemic PF (EPF) in Brazil and Tunisia. Frontiers Media S.A. 2022-05-27 /pmc/articles/PMC9186141/ /pubmed/35693761 http://dx.doi.org/10.3389/fimmu.2022.907424 Text en Copyright © 2022 Li, Aoki, Liu, Prisayanh, Valenzuela and Diaz https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Li, Ning
Aoki, Valeria
Liu, Zhi
Prisayanh, Phillip
Valenzuela, Jesus G.
Diaz, Luis A.
From Insect Bites to a Skin Autoimmune Disease: A Conceivable Pathway to Endemic Pemphigus Foliaceus
title From Insect Bites to a Skin Autoimmune Disease: A Conceivable Pathway to Endemic Pemphigus Foliaceus
title_full From Insect Bites to a Skin Autoimmune Disease: A Conceivable Pathway to Endemic Pemphigus Foliaceus
title_fullStr From Insect Bites to a Skin Autoimmune Disease: A Conceivable Pathway to Endemic Pemphigus Foliaceus
title_full_unstemmed From Insect Bites to a Skin Autoimmune Disease: A Conceivable Pathway to Endemic Pemphigus Foliaceus
title_short From Insect Bites to a Skin Autoimmune Disease: A Conceivable Pathway to Endemic Pemphigus Foliaceus
title_sort from insect bites to a skin autoimmune disease: a conceivable pathway to endemic pemphigus foliaceus
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186141/
https://www.ncbi.nlm.nih.gov/pubmed/35693761
http://dx.doi.org/10.3389/fimmu.2022.907424
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