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Triptolide promotes degradation of the unfolded gain-of-function Tp53(R175H/Y220C) mutant protein by initiating heat shock protein 70 transcription in non-small cell lung cancer
BACKGROUND: The mutation rate of the tumor protein P53 (TP53) has been reported to be greater than 50% in non-small cell lung cancer (NSCLC), and gain-of-function (GOF) mutations in unfolded P53 (TP53(R175H) and TP53(Y220C)) have been associated with poor prognosis. However, the best treatment for p...
Autores principales: | Zhou, Jie, Luo, Junwen, Li, Peiwei, Zhou, Yongjia, Li, Peichao, Wang, Fang, Mallio, Carlo Augusto, Rossi, Giulio, Jalal, Ahmed Hasnain, Filipovic, Nenad, Tian, Zhongxian, Zhao, Xiaogang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186163/ https://www.ncbi.nlm.nih.gov/pubmed/35693277 http://dx.doi.org/10.21037/tlcr-22-312 |
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