Triptolide promotes degradation of the unfolded gain-of-function Tp53(R175H/Y220C) mutant protein by initiating heat shock protein 70 transcription in non-small cell lung cancer

BACKGROUND: The mutation rate of the tumor protein P53 (TP53) has been reported to be greater than 50% in non-small cell lung cancer (NSCLC), and gain-of-function (GOF) mutations in unfolded P53 (TP53(R175H) and TP53(Y220C)) have been associated with poor prognosis. However, the best treatment for p...

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Detalles Bibliográficos
Autores principales: Zhou, Jie, Luo, Junwen, Li, Peiwei, Zhou, Yongjia, Li, Peichao, Wang, Fang, Mallio, Carlo Augusto, Rossi, Giulio, Jalal, Ahmed Hasnain, Filipovic, Nenad, Tian, Zhongxian, Zhao, Xiaogang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186163/
https://www.ncbi.nlm.nih.gov/pubmed/35693277
http://dx.doi.org/10.21037/tlcr-22-312

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