Endothelial cells give a boost to senescence surveillance

Senescence is a specialized form of cell cycle arrest induced in response to damage and stress. In certain settings, senescent cells can promote their own removal by recruitment of the immune system, a process that is thought to decline in efficiency with age. In this issue of Genes & Developmen...

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Detalles Bibliográficos
Autores principales: Sampaio Gonçalves, Daniel, Keyes, William M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2022
Materias:
Outlook
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186389/
https://www.ncbi.nlm.nih.gov/pubmed/35680423
http://dx.doi.org/10.1101/gad.349767.122
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author Sampaio Gonçalves, Daniel
Keyes, William M.
author_facet Sampaio Gonçalves, Daniel
Keyes, William M.
author_sort Sampaio Gonçalves, Daniel
collection PubMed
description Senescence is a specialized form of cell cycle arrest induced in response to damage and stress. In certain settings, senescent cells can promote their own removal by recruitment of the immune system, a process that is thought to decline in efficiency with age. In this issue of Genes & Development, Yin et al. (pp. 533–549) discover a surprising cross-talk where senescent cells instruct endothelial cells to help organize the clearance of the senescent population. This uncovers yet another layer of complexity in senescent cell biology, with implications for cancer treatment and aging.
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spelling pubmed-91863892022-11-01 Endothelial cells give a boost to senescence surveillance Sampaio Gonçalves, Daniel Keyes, William M. Genes Dev Outlook Senescence is a specialized form of cell cycle arrest induced in response to damage and stress. In certain settings, senescent cells can promote their own removal by recruitment of the immune system, a process that is thought to decline in efficiency with age. In this issue of Genes & Development, Yin et al. (pp. 533–549) discover a surprising cross-talk where senescent cells instruct endothelial cells to help organize the clearance of the senescent population. This uncovers yet another layer of complexity in senescent cell biology, with implications for cancer treatment and aging. Cold Spring Harbor Laboratory Press 2022-05-01 /pmc/articles/PMC9186389/ /pubmed/35680423 http://dx.doi.org/10.1101/gad.349767.122 Text en © 2022 Sampaio Gonçalves and Keyes; Published by Cold Spring Harbor Laboratory Press https://creativecommons.org/licenses/by-nc/4.0/This article is distributed exclusively by Cold Spring Harbor Laboratory Press for the first six months after the full-issue publication date (see http://genesdev.cshlp.org/site/misc/terms.xhtml). After six months, it is available under a Creative Commons License (Attribution-NonCommercial 4.0 International), as described at http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Outlook
Sampaio Gonçalves, Daniel
Keyes, William M.
Endothelial cells give a boost to senescence surveillance
title Endothelial cells give a boost to senescence surveillance
title_full Endothelial cells give a boost to senescence surveillance
title_fullStr Endothelial cells give a boost to senescence surveillance
title_full_unstemmed Endothelial cells give a boost to senescence surveillance
title_short Endothelial cells give a boost to senescence surveillance
title_sort endothelial cells give a boost to senescence surveillance
topic Outlook
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186389/
https://www.ncbi.nlm.nih.gov/pubmed/35680423
http://dx.doi.org/10.1101/gad.349767.122
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