Novel Small Molecule Tyrosine Kinase 2 Pseudokinase Ligands Block Cytokine-Induced TYK2-Mediated Signaling Pathways

A member of the Janus kinase (JAK) family, Tyrosine Kinase 2 (TYK2), is crucial in mediating various cytokine-signaling pathways such as interleukin-23 (IL23), interleukin-12 (IL12) and type I Interferons (IFN) which contribute to autoimmune disorders (e.g., psoriasis, lupus, and inflammatory bowel...

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Detalles Bibliográficos
Autores principales: Zhou, Yu, Li, Xin, Shen, Ru, Wang, Xiangzhu, Zhang, Fan, Liu, Suxing, Li, Di, Liu, Jian, Li, Puhui, Yan, Yinfa, Dong, Ping, Zhang, Zhigao, Wu, Heping, Zhuang, Linghang, Chowdhury, Rasheduzzaman, Miller, Matthew, Issa, Mena, Mao, Yuchang, Chen, Hongli, Feng, Jun, Li, Jing, Bai, Chang, He, Feng, Tao, Weikang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186491/
https://www.ncbi.nlm.nih.gov/pubmed/35693820
http://dx.doi.org/10.3389/fimmu.2022.884399

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