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NcRNAs-mediated P2RX1 expression correlates with clinical outcomes and immune infiltration in patients with breast invasive carcinoma

The development of novel treatments for breast invasive carcinoma (BC) has been stagnant. P2RX1, a member of the purinergic receptor family, has been found to have a prognostic impact in several tumors. Therefore, we analyzed the expression pattern of P2RX1 in pan-cancers including BC and its impact...

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Autores principales: Xu, Yiyue, Zou, Bing, Fan, Bingjie, Li, Butuo, Yu, Jinming, Wang, Linlin, Zhang, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186779/
https://www.ncbi.nlm.nih.gov/pubmed/35585027
http://dx.doi.org/10.18632/aging.204087
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author Xu, Yiyue
Zou, Bing
Fan, Bingjie
Li, Butuo
Yu, Jinming
Wang, Linlin
Zhang, Jin
author_facet Xu, Yiyue
Zou, Bing
Fan, Bingjie
Li, Butuo
Yu, Jinming
Wang, Linlin
Zhang, Jin
author_sort Xu, Yiyue
collection PubMed
description The development of novel treatments for breast invasive carcinoma (BC) has been stagnant. P2RX1, a member of the purinergic receptor family, has been found to have a prognostic impact in several tumors. Therefore, we analyzed the expression pattern of P2RX1 in pan-cancers including BC and its impact on survival and found that the expression level of P2RX1 was lower in BC compared with para-cancerous tissues, and higher P2RX1 expression indicated better prognoses. But real-time quantitative reverse transcription PCR (RT-qPCR) and Western blot detected that the P2RX1 expression in normal mammary epithelial cells was lower than that in tumor cells. Then we comprehensively analyzed the regulatory mechanism and protein-protein interaction network, and found that P2RX1 was significantly positively linked with immune cell infiltration and immune checkpoints.
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spelling pubmed-91867792022-06-14 NcRNAs-mediated P2RX1 expression correlates with clinical outcomes and immune infiltration in patients with breast invasive carcinoma Xu, Yiyue Zou, Bing Fan, Bingjie Li, Butuo Yu, Jinming Wang, Linlin Zhang, Jin Aging (Albany NY) Research Paper The development of novel treatments for breast invasive carcinoma (BC) has been stagnant. P2RX1, a member of the purinergic receptor family, has been found to have a prognostic impact in several tumors. Therefore, we analyzed the expression pattern of P2RX1 in pan-cancers including BC and its impact on survival and found that the expression level of P2RX1 was lower in BC compared with para-cancerous tissues, and higher P2RX1 expression indicated better prognoses. But real-time quantitative reverse transcription PCR (RT-qPCR) and Western blot detected that the P2RX1 expression in normal mammary epithelial cells was lower than that in tumor cells. Then we comprehensively analyzed the regulatory mechanism and protein-protein interaction network, and found that P2RX1 was significantly positively linked with immune cell infiltration and immune checkpoints. Impact Journals 2022-05-18 /pmc/articles/PMC9186779/ /pubmed/35585027 http://dx.doi.org/10.18632/aging.204087 Text en Copyright: © 2022 Xu et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Xu, Yiyue
Zou, Bing
Fan, Bingjie
Li, Butuo
Yu, Jinming
Wang, Linlin
Zhang, Jin
NcRNAs-mediated P2RX1 expression correlates with clinical outcomes and immune infiltration in patients with breast invasive carcinoma
title NcRNAs-mediated P2RX1 expression correlates with clinical outcomes and immune infiltration in patients with breast invasive carcinoma
title_full NcRNAs-mediated P2RX1 expression correlates with clinical outcomes and immune infiltration in patients with breast invasive carcinoma
title_fullStr NcRNAs-mediated P2RX1 expression correlates with clinical outcomes and immune infiltration in patients with breast invasive carcinoma
title_full_unstemmed NcRNAs-mediated P2RX1 expression correlates with clinical outcomes and immune infiltration in patients with breast invasive carcinoma
title_short NcRNAs-mediated P2RX1 expression correlates with clinical outcomes and immune infiltration in patients with breast invasive carcinoma
title_sort ncrnas-mediated p2rx1 expression correlates with clinical outcomes and immune infiltration in patients with breast invasive carcinoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186779/
https://www.ncbi.nlm.nih.gov/pubmed/35585027
http://dx.doi.org/10.18632/aging.204087
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