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Incidence and relative risk factors in posttransplant diabetes mellitus patients: a retrospective cohort study

BACKGROUND: Posttransplant diabetes mellitus (PTDM) has a long-term impact on kidney transplantation outcomes, such as graft and patient survival. The incidence and risk factors of PTDM are well studied, but long-term follow-up results remain unavailable. We examined the long-term incidence and rela...

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Autores principales: Cheng, Ching-Yao, Feng, Yu-Tung, Wang, Hue-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Transplantation 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186811/
https://www.ncbi.nlm.nih.gov/pubmed/35770107
http://dx.doi.org/10.4285/kjt.20.0026
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author Cheng, Ching-Yao
Feng, Yu-Tung
Wang, Hue-Yu
author_facet Cheng, Ching-Yao
Feng, Yu-Tung
Wang, Hue-Yu
author_sort Cheng, Ching-Yao
collection PubMed
description BACKGROUND: Posttransplant diabetes mellitus (PTDM) has a long-term impact on kidney transplantation outcomes, such as graft and patient survival. The incidence and risk factors of PTDM are well studied, but long-term follow-up results remain unavailable. We examined the long-term incidence and relative risk factors of PTDM. METHODS: A hospital information system database for kidney transplant recipients (KTRs) for a transplantation center between 1983 and 2018 was used to perform this retrospective cohort study. KTRs with DM diagnosis and continuous use of hypoglycemic agents for more than 3 months were defined as having PTDM. Demographics and comorbidities before transplantation were also collected. Kaplan-Meier analyses were used to determine the cumulative incidence and relative risk factors. RESULTS: A total of 296 PTDM cases were confirmed (28.46%) in this study. An increased cumulative incidence associated with age was noted, which was significantly increased in those aged ≥40 years. Male sex, hypertension, hyperlipidemia before transplantation, cytomegalovirus (CMV) infection, and tacrolimus-based regimens were also risk factors. No significant correlation was found between the development of PTDM and the increase of human leukocyte antigen mismatches, the primary causes of end-stage renal disease, and acute rejection. CONCLUSIONS: PTDM incidence was high in this cohort study. Characteristics such as age ≥40 years, tacrolimus use, comorbidity of hypertension and hyperlipidemia before transplantation, and CMV infection were associated with a high risk of PTDM. Monitoring and adjusting preventable risk factors such as CMV infection might be useful to prevent PTDM.
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spelling pubmed-91868112022-06-28 Incidence and relative risk factors in posttransplant diabetes mellitus patients: a retrospective cohort study Cheng, Ching-Yao Feng, Yu-Tung Wang, Hue-Yu Korean J Transplant Original Article BACKGROUND: Posttransplant diabetes mellitus (PTDM) has a long-term impact on kidney transplantation outcomes, such as graft and patient survival. The incidence and risk factors of PTDM are well studied, but long-term follow-up results remain unavailable. We examined the long-term incidence and relative risk factors of PTDM. METHODS: A hospital information system database for kidney transplant recipients (KTRs) for a transplantation center between 1983 and 2018 was used to perform this retrospective cohort study. KTRs with DM diagnosis and continuous use of hypoglycemic agents for more than 3 months were defined as having PTDM. Demographics and comorbidities before transplantation were also collected. Kaplan-Meier analyses were used to determine the cumulative incidence and relative risk factors. RESULTS: A total of 296 PTDM cases were confirmed (28.46%) in this study. An increased cumulative incidence associated with age was noted, which was significantly increased in those aged ≥40 years. Male sex, hypertension, hyperlipidemia before transplantation, cytomegalovirus (CMV) infection, and tacrolimus-based regimens were also risk factors. No significant correlation was found between the development of PTDM and the increase of human leukocyte antigen mismatches, the primary causes of end-stage renal disease, and acute rejection. CONCLUSIONS: PTDM incidence was high in this cohort study. Characteristics such as age ≥40 years, tacrolimus use, comorbidity of hypertension and hyperlipidemia before transplantation, and CMV infection were associated with a high risk of PTDM. Monitoring and adjusting preventable risk factors such as CMV infection might be useful to prevent PTDM. The Korean Society for Transplantation 2020-12-31 2020-12-16 /pmc/articles/PMC9186811/ /pubmed/35770107 http://dx.doi.org/10.4285/kjt.20.0026 Text en Copyright © 2020 The Korean Society for Transplantation https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Cheng, Ching-Yao
Feng, Yu-Tung
Wang, Hue-Yu
Incidence and relative risk factors in posttransplant diabetes mellitus patients: a retrospective cohort study
title Incidence and relative risk factors in posttransplant diabetes mellitus patients: a retrospective cohort study
title_full Incidence and relative risk factors in posttransplant diabetes mellitus patients: a retrospective cohort study
title_fullStr Incidence and relative risk factors in posttransplant diabetes mellitus patients: a retrospective cohort study
title_full_unstemmed Incidence and relative risk factors in posttransplant diabetes mellitus patients: a retrospective cohort study
title_short Incidence and relative risk factors in posttransplant diabetes mellitus patients: a retrospective cohort study
title_sort incidence and relative risk factors in posttransplant diabetes mellitus patients: a retrospective cohort study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9186811/
https://www.ncbi.nlm.nih.gov/pubmed/35770107
http://dx.doi.org/10.4285/kjt.20.0026
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