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Gatekeeping role of Nf2/Merlin in vascular tip EC induction through suppression of VEGFR2 internalization

In sprouting angiogenesis, the precise mechanisms underlying how intracellular vascular endothelial growth factor receptor 2 (VEGFR2) signaling is higher in one endothelial cell (EC) compared with its neighbor and acquires the tip EC phenotype under a similar external cue are elusive. Here, we show...

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Detalles Bibliográficos
Autores principales: Bae, Jung Hyun, Yang, Myung Jin, Jeong, Seung-hwan, Kim, JungMo, Hong, Seon Pyo, Kim, Jin Woo, Kim, Yoo Hyung, Koh, Gou Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187237/
https://www.ncbi.nlm.nih.gov/pubmed/35687678
http://dx.doi.org/10.1126/sciadv.abn2611