The risk variant rs11836367 contributes to breast cancer onset and metastasis by attenuating Wnt signaling via regulating NTN4 expression

Most genome-wide association study (GWAS)–identified breast cancer–associated causal variants remain uncharacterized. To provide a framework of understanding GWAS-identified variants to function, we performed a comprehensive study of noncoding regulatory variants at the NTN4 locus (12q22) and NTN4 g...

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Detalles Bibliográficos
Autores principales: Yang, Han, Ting, Xia, Geng, Yue-Hang, Xie, Yuntao, Nierenberg, Jovia L., Huo, Yan-Fei, Zhou, Yan-Ting, Huang, Yang, Yu, Yu-Qing, Yu, Xin-Yao, Li, Xiao-Fei, Ziv, Elad, Zhang, Hongquan, Fang, Wei-Gang, Shen, Yin, Tian, Xin-Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187238/
https://www.ncbi.nlm.nih.gov/pubmed/35687692
http://dx.doi.org/10.1126/sciadv.abn3509

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