Cargando…

Outcomes after Thymectomy in Patients with Thymomatous Myasthenia Gravis

Objectives  This article describes the clinical outcomes after thymectomy in patients with thymomatous myasthenia gravis (T-MG) managed in the department of thoracic surgery of Hassan II University Hospital of Fez, Fez, Morocco. Materials and Methods  We performed a retrospective analysis of medical...

Descripción completa

Detalles Bibliográficos
Autores principales: Rabiou, Sani, Toudou-Daouda, Moussa, Lakranbi, Marwane, Issoufou, Ibrahim, Ouadnouni, Yassine, Smahi, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Thieme Medical and Scientific Publishers Pvt. Ltd. 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187376/
https://www.ncbi.nlm.nih.gov/pubmed/35694069
http://dx.doi.org/10.1055/s-0042-1743444
_version_ 1784725154161491968
author Rabiou, Sani
Toudou-Daouda, Moussa
Lakranbi, Marwane
Issoufou, Ibrahim
Ouadnouni, Yassine
Smahi, Mohamed
author_facet Rabiou, Sani
Toudou-Daouda, Moussa
Lakranbi, Marwane
Issoufou, Ibrahim
Ouadnouni, Yassine
Smahi, Mohamed
author_sort Rabiou, Sani
collection PubMed
description Objectives  This article describes the clinical outcomes after thymectomy in patients with thymomatous myasthenia gravis (T-MG) managed in the department of thoracic surgery of Hassan II University Hospital of Fez, Fez, Morocco. Materials and Methods  We performed a retrospective analysis of medical records of 16 patients with T-MG between January 2009 and January 2017. Results  There were 11 women and 5 men with a median age of 40 years at the thymectomy time and a median time of onset of symptoms to thymectomy of 12 months. At the preoperative evaluation (Myasthenia Gravis Foundation of America [MGFA] clinical classification), 7 patients were class II, 7 class III, and 2 class IV. Nine patients were in Masaoka stage I, and the remaining 7 patients stage II. We recorded one case of postoperative myasthenic crisis. At 3 years of follow-up after thymectomy, 6 patients had complete stable remission and the other 10 patients improved. Of these patients with clinical improvement, 6 patients were in MGFA class I and the remaining 4 patients class II. Conclusion  The present study shows the beneficial effect of thymectomy in patients with T-MG. Postoperative clinical outcomes seem to be better when the preoperative severity of myasthenic symptoms is mild (MGFA class II).
format Online
Article
Text
id pubmed-9187376
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
record_format MEDLINE/PubMed
spelling pubmed-91873762022-06-11 Outcomes after Thymectomy in Patients with Thymomatous Myasthenia Gravis Rabiou, Sani Toudou-Daouda, Moussa Lakranbi, Marwane Issoufou, Ibrahim Ouadnouni, Yassine Smahi, Mohamed J Neurosci Rural Pract Objectives  This article describes the clinical outcomes after thymectomy in patients with thymomatous myasthenia gravis (T-MG) managed in the department of thoracic surgery of Hassan II University Hospital of Fez, Fez, Morocco. Materials and Methods  We performed a retrospective analysis of medical records of 16 patients with T-MG between January 2009 and January 2017. Results  There were 11 women and 5 men with a median age of 40 years at the thymectomy time and a median time of onset of symptoms to thymectomy of 12 months. At the preoperative evaluation (Myasthenia Gravis Foundation of America [MGFA] clinical classification), 7 patients were class II, 7 class III, and 2 class IV. Nine patients were in Masaoka stage I, and the remaining 7 patients stage II. We recorded one case of postoperative myasthenic crisis. At 3 years of follow-up after thymectomy, 6 patients had complete stable remission and the other 10 patients improved. Of these patients with clinical improvement, 6 patients were in MGFA class I and the remaining 4 patients class II. Conclusion  The present study shows the beneficial effect of thymectomy in patients with T-MG. Postoperative clinical outcomes seem to be better when the preoperative severity of myasthenic symptoms is mild (MGFA class II). Thieme Medical and Scientific Publishers Pvt. Ltd. 2022-03-09 /pmc/articles/PMC9187376/ /pubmed/35694069 http://dx.doi.org/10.1055/s-0042-1743444 Text en Association for Helping Neurosurgical Sick People. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. ( https://creativecommons.org/licenses/by-nc-nd/4.0/ ) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License, which permits unrestricted reproduction and distribution, for non-commercial purposes only; and use and reproduction, but not distribution, of adapted material for non-commercial purposes only, provided the original work is properly cited.
spellingShingle Rabiou, Sani
Toudou-Daouda, Moussa
Lakranbi, Marwane
Issoufou, Ibrahim
Ouadnouni, Yassine
Smahi, Mohamed
Outcomes after Thymectomy in Patients with Thymomatous Myasthenia Gravis
title Outcomes after Thymectomy in Patients with Thymomatous Myasthenia Gravis
title_full Outcomes after Thymectomy in Patients with Thymomatous Myasthenia Gravis
title_fullStr Outcomes after Thymectomy in Patients with Thymomatous Myasthenia Gravis
title_full_unstemmed Outcomes after Thymectomy in Patients with Thymomatous Myasthenia Gravis
title_short Outcomes after Thymectomy in Patients with Thymomatous Myasthenia Gravis
title_sort outcomes after thymectomy in patients with thymomatous myasthenia gravis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187376/
https://www.ncbi.nlm.nih.gov/pubmed/35694069
http://dx.doi.org/10.1055/s-0042-1743444
work_keys_str_mv AT rabiousani outcomesafterthymectomyinpatientswiththymomatousmyastheniagravis
AT toudoudaoudamoussa outcomesafterthymectomyinpatientswiththymomatousmyastheniagravis
AT lakranbimarwane outcomesafterthymectomyinpatientswiththymomatousmyastheniagravis
AT issoufouibrahim outcomesafterthymectomyinpatientswiththymomatousmyastheniagravis
AT ouadnouniyassine outcomesafterthymectomyinpatientswiththymomatousmyastheniagravis
AT smahimohamed outcomesafterthymectomyinpatientswiththymomatousmyastheniagravis