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Bone material strength index as measured by in vivo impact microindentation is normal in subjects with high-energy trauma fractures

SUMMARY: Bone material properties were assessed using impact microindentation in patients with high-energy trauma fractures. Compared to patients with low-energy trauma fractures, bone material strength index was significantly higher in patients with high-energy trauma fractures, and did not differ...

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Autores principales: Schoeb, M., Winter, E. M., Malgo, F., Schipper, I. B., van der Wal, R. J. P., Papapoulos, S. E., Appelman-Dijkstra, N. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer London 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187533/
https://www.ncbi.nlm.nih.gov/pubmed/35307747
http://dx.doi.org/10.1007/s00198-022-06368-0
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author Schoeb, M.
Winter, E. M.
Malgo, F.
Schipper, I. B.
van der Wal, R. J. P.
Papapoulos, S. E.
Appelman-Dijkstra, N. M.
author_facet Schoeb, M.
Winter, E. M.
Malgo, F.
Schipper, I. B.
van der Wal, R. J. P.
Papapoulos, S. E.
Appelman-Dijkstra, N. M.
author_sort Schoeb, M.
collection PubMed
description SUMMARY: Bone material properties were assessed using impact microindentation in patients with high-energy trauma fractures. Compared to patients with low-energy trauma fractures, bone material strength index was significantly higher in patients with high-energy trauma fractures, and did not differ between patients with osteopenia and those with osteoporosis within each trauma group. INTRODUCTION: Impact microindentation (IMI) is a technique to assess tissue-level properties of bone at the tibia. Bone material strength index (BMSi), measured by IMI, is decreased in patients with low-energy trauma fractures, independently of areal bone mineral density (aBMD), but there is no information about BMSi in patients with high-energy trauma fractures. In the present study, we evaluated tissue-level properties of bone with IMI in patients with high-energy trauma fractures. METHODS: BMSi was measured 3.0 months (IQR 2.0–5.8) after the fracture in 40 patients with high-energy trauma and 40 age- and gender-matched controls with low-energy trauma fractures using the OsteoProbe® device. RESULTS: Mean age of high- and low-energy trauma patients was 57.7 ± 9.1 and 57.2 ± 7.7 years, respectively (p = 0.78). Fracture types were comparable in high- vs low-energy trauma patients. Lumbar spine (LS)-aBMD, but not femoral neck (FN)-aBMD, was higher in high- than in low-energy trauma patients (LS 0.96 ± 0.13 vs 0.89 ± 0.13 g/cm(2), p = 0.02; FN 0.75 ± 0.09 vs 0.72 ± 0.09 g/cm(2), p = 0.09). BMSi was significantly higher in high- than in low-energy trauma patients (84.4 ± 5.0 vs 78.0 ± 4.6, p = 0.001), also after adjusting for aBMD (p = 0.003). In addition, BMSi did not differ between patients with osteopenia and those with osteoporosis within each trauma group. CONCLUSION: Our data demonstrate that BMSi and LS-aBMD, but not FN-aBMD, are significantly higher in high-energy trauma patients compared to matched controls with similar fractures from low-energy trauma. Further studies of non-osteoporotic patients with high-energy trauma fracture with measurements of BMSi are warranted to determine whether IMI might help in identifying those with reduced bone strength.
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spelling pubmed-91875332022-06-12 Bone material strength index as measured by in vivo impact microindentation is normal in subjects with high-energy trauma fractures Schoeb, M. Winter, E. M. Malgo, F. Schipper, I. B. van der Wal, R. J. P. Papapoulos, S. E. Appelman-Dijkstra, N. M. Osteoporos Int Original Article SUMMARY: Bone material properties were assessed using impact microindentation in patients with high-energy trauma fractures. Compared to patients with low-energy trauma fractures, bone material strength index was significantly higher in patients with high-energy trauma fractures, and did not differ between patients with osteopenia and those with osteoporosis within each trauma group. INTRODUCTION: Impact microindentation (IMI) is a technique to assess tissue-level properties of bone at the tibia. Bone material strength index (BMSi), measured by IMI, is decreased in patients with low-energy trauma fractures, independently of areal bone mineral density (aBMD), but there is no information about BMSi in patients with high-energy trauma fractures. In the present study, we evaluated tissue-level properties of bone with IMI in patients with high-energy trauma fractures. METHODS: BMSi was measured 3.0 months (IQR 2.0–5.8) after the fracture in 40 patients with high-energy trauma and 40 age- and gender-matched controls with low-energy trauma fractures using the OsteoProbe® device. RESULTS: Mean age of high- and low-energy trauma patients was 57.7 ± 9.1 and 57.2 ± 7.7 years, respectively (p = 0.78). Fracture types were comparable in high- vs low-energy trauma patients. Lumbar spine (LS)-aBMD, but not femoral neck (FN)-aBMD, was higher in high- than in low-energy trauma patients (LS 0.96 ± 0.13 vs 0.89 ± 0.13 g/cm(2), p = 0.02; FN 0.75 ± 0.09 vs 0.72 ± 0.09 g/cm(2), p = 0.09). BMSi was significantly higher in high- than in low-energy trauma patients (84.4 ± 5.0 vs 78.0 ± 4.6, p = 0.001), also after adjusting for aBMD (p = 0.003). In addition, BMSi did not differ between patients with osteopenia and those with osteoporosis within each trauma group. CONCLUSION: Our data demonstrate that BMSi and LS-aBMD, but not FN-aBMD, are significantly higher in high-energy trauma patients compared to matched controls with similar fractures from low-energy trauma. Further studies of non-osteoporotic patients with high-energy trauma fracture with measurements of BMSi are warranted to determine whether IMI might help in identifying those with reduced bone strength. Springer London 2022-03-21 2022 /pmc/articles/PMC9187533/ /pubmed/35307747 http://dx.doi.org/10.1007/s00198-022-06368-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) .
spellingShingle Original Article
Schoeb, M.
Winter, E. M.
Malgo, F.
Schipper, I. B.
van der Wal, R. J. P.
Papapoulos, S. E.
Appelman-Dijkstra, N. M.
Bone material strength index as measured by in vivo impact microindentation is normal in subjects with high-energy trauma fractures
title Bone material strength index as measured by in vivo impact microindentation is normal in subjects with high-energy trauma fractures
title_full Bone material strength index as measured by in vivo impact microindentation is normal in subjects with high-energy trauma fractures
title_fullStr Bone material strength index as measured by in vivo impact microindentation is normal in subjects with high-energy trauma fractures
title_full_unstemmed Bone material strength index as measured by in vivo impact microindentation is normal in subjects with high-energy trauma fractures
title_short Bone material strength index as measured by in vivo impact microindentation is normal in subjects with high-energy trauma fractures
title_sort bone material strength index as measured by in vivo impact microindentation is normal in subjects with high-energy trauma fractures
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187533/
https://www.ncbi.nlm.nih.gov/pubmed/35307747
http://dx.doi.org/10.1007/s00198-022-06368-0
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