Hypocomplementemia in primary Sjogren’s syndrome: association with serological, clinical features, and outcome

OBJECTIVE: The aim of the present study was to assess the clinical characteristic of hypocomplementemia (HC) in primary Sjogren’s syndrome (pSS), and to address possible risk factors and the prognosis associated with HC in pSS patients. METHODS: pSS patients with HC in Hebei General Hospital from Se...

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Autores principales: Lin, Wei, Xin, Zhifei, Wang, Jialan, Ren, Xiuying, Liu, Yixuan, Yang, Liu, Guo, Shaoying, Yang, Yupeng, Li, Yang, Cao, Jingjing, Ning, Xiaoran, Liu, Meilu, Su, Yashuang, Sun, Lijun, Zhang, Fengxiao, Zhang, Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
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Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187545/
https://www.ncbi.nlm.nih.gov/pubmed/35348930
http://dx.doi.org/10.1007/s10067-022-06135-w
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author Lin, Wei
Xin, Zhifei
Wang, Jialan
Ren, Xiuying
Liu, Yixuan
Yang, Liu
Guo, Shaoying
Yang, Yupeng
Li, Yang
Cao, Jingjing
Ning, Xiaoran
Liu, Meilu
Su, Yashuang
Sun, Lijun
Zhang, Fengxiao
Zhang, Wen
author_facet Lin, Wei
Xin, Zhifei
Wang, Jialan
Ren, Xiuying
Liu, Yixuan
Yang, Liu
Guo, Shaoying
Yang, Yupeng
Li, Yang
Cao, Jingjing
Ning, Xiaoran
Liu, Meilu
Su, Yashuang
Sun, Lijun
Zhang, Fengxiao
Zhang, Wen
author_sort Lin, Wei
collection PubMed
description OBJECTIVE: The aim of the present study was to assess the clinical characteristic of hypocomplementemia (HC) in primary Sjogren’s syndrome (pSS), and to address possible risk factors and the prognosis associated with HC in pSS patients. METHODS: pSS patients with HC in Hebei General Hospital from September 2016 to March 2019 were retrospectively analyzed and compared to those with normocomplementemia (NC). Logistic regression analysis was used to detect risk factors. RESULTS: Of the 333 patients with pSS, 84 patients (25.23%) were presented with HC at diagnosis. The presence of hyper-IgG and anti-Ro52 antibodies was significantly more common in patients with HC. In addition to systemic involvement, pSS patients with HC had more hematological, renal, and nervous system involvement, and received more immunosuppressant treatments than NC group (p < 0.05). ESSDAI score was significantly higher in patients with HC (p < 0.05). Multivariate logistic analysis indicated that leukopenia (OR = 2.23) and hyper-IgG (OR = 2.13) were independent risk factors for pSS with HC. In addition, profound CD16/CD56+ NK-cell lymphopenia was found in pSS-HC patients. More pSS patients developed SLE in the HC group than NC group (4.76% vs. 0.80%, p = 0.04) during the follow-up. CONCLUSION: HC was not an uncommon manifestation of pSS and had an independent association with the main clinical and immunological features. Patients with pSS-HC had an increased possibility to develop SLE that required more positive treatment with glucocorticoids and immunosuppressants. KEY POINTS: • Hypocomplementemia had an independent association with the main clinical and immunological features in primary Sjogren’s syndrome patients. • ESSDAI score was significantly higher in patients with hypocomplementemia. • The pSS patients with hypocomplementemia had an increased possibility to develop SLE. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10067-022-06135-w.
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spelling pubmed-91875452022-06-12 Hypocomplementemia in primary Sjogren’s syndrome: association with serological, clinical features, and outcome Lin, Wei Xin, Zhifei Wang, Jialan Ren, Xiuying Liu, Yixuan Yang, Liu Guo, Shaoying Yang, Yupeng Li, Yang Cao, Jingjing Ning, Xiaoran Liu, Meilu Su, Yashuang Sun, Lijun Zhang, Fengxiao Zhang, Wen Clin Rheumatol Original Article OBJECTIVE: The aim of the present study was to assess the clinical characteristic of hypocomplementemia (HC) in primary Sjogren’s syndrome (pSS), and to address possible risk factors and the prognosis associated with HC in pSS patients. METHODS: pSS patients with HC in Hebei General Hospital from September 2016 to March 2019 were retrospectively analyzed and compared to those with normocomplementemia (NC). Logistic regression analysis was used to detect risk factors. RESULTS: Of the 333 patients with pSS, 84 patients (25.23%) were presented with HC at diagnosis. The presence of hyper-IgG and anti-Ro52 antibodies was significantly more common in patients with HC. In addition to systemic involvement, pSS patients with HC had more hematological, renal, and nervous system involvement, and received more immunosuppressant treatments than NC group (p < 0.05). ESSDAI score was significantly higher in patients with HC (p < 0.05). Multivariate logistic analysis indicated that leukopenia (OR = 2.23) and hyper-IgG (OR = 2.13) were independent risk factors for pSS with HC. In addition, profound CD16/CD56+ NK-cell lymphopenia was found in pSS-HC patients. More pSS patients developed SLE in the HC group than NC group (4.76% vs. 0.80%, p = 0.04) during the follow-up. CONCLUSION: HC was not an uncommon manifestation of pSS and had an independent association with the main clinical and immunological features. Patients with pSS-HC had an increased possibility to develop SLE that required more positive treatment with glucocorticoids and immunosuppressants. KEY POINTS: • Hypocomplementemia had an independent association with the main clinical and immunological features in primary Sjogren’s syndrome patients. • ESSDAI score was significantly higher in patients with hypocomplementemia. • The pSS patients with hypocomplementemia had an increased possibility to develop SLE. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10067-022-06135-w. Springer International Publishing 2022-03-29 2022 /pmc/articles/PMC9187545/ /pubmed/35348930 http://dx.doi.org/10.1007/s10067-022-06135-w Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Lin, Wei
Xin, Zhifei
Wang, Jialan
Ren, Xiuying
Liu, Yixuan
Yang, Liu
Guo, Shaoying
Yang, Yupeng
Li, Yang
Cao, Jingjing
Ning, Xiaoran
Liu, Meilu
Su, Yashuang
Sun, Lijun
Zhang, Fengxiao
Zhang, Wen
Hypocomplementemia in primary Sjogren’s syndrome: association with serological, clinical features, and outcome
title Hypocomplementemia in primary Sjogren’s syndrome: association with serological, clinical features, and outcome
title_full Hypocomplementemia in primary Sjogren’s syndrome: association with serological, clinical features, and outcome
title_fullStr Hypocomplementemia in primary Sjogren’s syndrome: association with serological, clinical features, and outcome
title_full_unstemmed Hypocomplementemia in primary Sjogren’s syndrome: association with serological, clinical features, and outcome
title_short Hypocomplementemia in primary Sjogren’s syndrome: association with serological, clinical features, and outcome
title_sort hypocomplementemia in primary sjogren’s syndrome: association with serological, clinical features, and outcome
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187545/
https://www.ncbi.nlm.nih.gov/pubmed/35348930
http://dx.doi.org/10.1007/s10067-022-06135-w
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