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Human immunodeficiency virus-1 Tat exerts its neurotoxic effects by downregulating Sonic hedgehog signaling

We previously showed that HIV-1 can alter the expression of tight junction proteins by downregulating Sonic hedgehog (Shh) signaling, thereby disrupting blood–brain barrier (BBB) integrity. In this study, we employed a conditional, CNS specific, Tat transgenic murine model to investigate if HIV-Tat...

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Detalles Bibliográficos
Autores principales:	khan, Irfan A., Worrad, Arthur H., Singh, Meera V., Maggirwar, Sanjay B., Singh, Vir B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2022
Materias:	Short Communication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187557/ https://www.ncbi.nlm.nih.gov/pubmed/35181862 http://dx.doi.org/10.1007/s13365-022-01061-8

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