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Atherogenic index of plasma is associated with epicardial adipose tissue volume assessed on coronary computed tomography angiography

The atherogenic index of plasma (AIP) is a novel biomarker of atherogenic dyslipidaemia (AD), but its relationship with cardiac adipose tissue depots is unknown. We aimed to assess the association of AD with cardiac adipose tissue parameters on coronary computed tomography angiography (CCTA). We stu...

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Autores principales: Yuvaraj, Jeremy, Isa, Mourushi, Che, Zhu Chung, Lim, Egynne, Nerlekar, Nitesh, Nicholls, Stephen J., Seneviratne, Sujith, Lin, Andrew, Dey, Damini, Wong, Dennis T. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187675/
https://www.ncbi.nlm.nih.gov/pubmed/35688850
http://dx.doi.org/10.1038/s41598-022-13479-5
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author Yuvaraj, Jeremy
Isa, Mourushi
Che, Zhu Chung
Lim, Egynne
Nerlekar, Nitesh
Nicholls, Stephen J.
Seneviratne, Sujith
Lin, Andrew
Dey, Damini
Wong, Dennis T. L.
author_facet Yuvaraj, Jeremy
Isa, Mourushi
Che, Zhu Chung
Lim, Egynne
Nerlekar, Nitesh
Nicholls, Stephen J.
Seneviratne, Sujith
Lin, Andrew
Dey, Damini
Wong, Dennis T. L.
author_sort Yuvaraj, Jeremy
collection PubMed
description The atherogenic index of plasma (AIP) is a novel biomarker of atherogenic dyslipidaemia (AD), but its relationship with cardiac adipose tissue depots is unknown. We aimed to assess the association of AD with cardiac adipose tissue parameters on coronary computed tomography angiography (CCTA). We studied 161 patients who underwent CCTA between 2008 and 2011 (age 59.0 ± 14.0 years). AD was defined as triglyceride (TG) > 1.7 mmol/L and HDL < 1.0 mmol/L (n = 34). AIP was defined as the base 10 logarithmic ratio of TG to HDL. Plaque burden was assessed using the CT-Leaman score (CT-LeSc). We studied volume and attenuation of epicardial adipose tissue (EAT-v and EAT-a) and pericoronary adipose tissue (PCAT-v and PCAT-a) on CCTA using semi-automated software. Patients with AD had higher PCAT-v (p = 0.042) and EAT-v (p = 0.041). AIP was associated with EAT-v (p = 0.006), type II diabetes (p = 0.009) and male sex (p < 0.001) and correlated with CT-LeSc (p = 0.040). On multivariable analysis, AIP was associated with EAT-v ≥ 52.3 cm(3), age, male sex and type II diabetes when corrected for traditional risk factors and plaque burden. AIP is associated with increased EAT volume, but not PCAT-a, after multivariable adjustment. These findings indicate AIP is associated with adverse adipose tissue changes which may increase coronary risk.
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spelling pubmed-91876752022-06-12 Atherogenic index of plasma is associated with epicardial adipose tissue volume assessed on coronary computed tomography angiography Yuvaraj, Jeremy Isa, Mourushi Che, Zhu Chung Lim, Egynne Nerlekar, Nitesh Nicholls, Stephen J. Seneviratne, Sujith Lin, Andrew Dey, Damini Wong, Dennis T. L. Sci Rep Article The atherogenic index of plasma (AIP) is a novel biomarker of atherogenic dyslipidaemia (AD), but its relationship with cardiac adipose tissue depots is unknown. We aimed to assess the association of AD with cardiac adipose tissue parameters on coronary computed tomography angiography (CCTA). We studied 161 patients who underwent CCTA between 2008 and 2011 (age 59.0 ± 14.0 years). AD was defined as triglyceride (TG) > 1.7 mmol/L and HDL < 1.0 mmol/L (n = 34). AIP was defined as the base 10 logarithmic ratio of TG to HDL. Plaque burden was assessed using the CT-Leaman score (CT-LeSc). We studied volume and attenuation of epicardial adipose tissue (EAT-v and EAT-a) and pericoronary adipose tissue (PCAT-v and PCAT-a) on CCTA using semi-automated software. Patients with AD had higher PCAT-v (p = 0.042) and EAT-v (p = 0.041). AIP was associated with EAT-v (p = 0.006), type II diabetes (p = 0.009) and male sex (p < 0.001) and correlated with CT-LeSc (p = 0.040). On multivariable analysis, AIP was associated with EAT-v ≥ 52.3 cm(3), age, male sex and type II diabetes when corrected for traditional risk factors and plaque burden. AIP is associated with increased EAT volume, but not PCAT-a, after multivariable adjustment. These findings indicate AIP is associated with adverse adipose tissue changes which may increase coronary risk. Nature Publishing Group UK 2022-06-10 /pmc/articles/PMC9187675/ /pubmed/35688850 http://dx.doi.org/10.1038/s41598-022-13479-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Yuvaraj, Jeremy
Isa, Mourushi
Che, Zhu Chung
Lim, Egynne
Nerlekar, Nitesh
Nicholls, Stephen J.
Seneviratne, Sujith
Lin, Andrew
Dey, Damini
Wong, Dennis T. L.
Atherogenic index of plasma is associated with epicardial adipose tissue volume assessed on coronary computed tomography angiography
title Atherogenic index of plasma is associated with epicardial adipose tissue volume assessed on coronary computed tomography angiography
title_full Atherogenic index of plasma is associated with epicardial adipose tissue volume assessed on coronary computed tomography angiography
title_fullStr Atherogenic index of plasma is associated with epicardial adipose tissue volume assessed on coronary computed tomography angiography
title_full_unstemmed Atherogenic index of plasma is associated with epicardial adipose tissue volume assessed on coronary computed tomography angiography
title_short Atherogenic index of plasma is associated with epicardial adipose tissue volume assessed on coronary computed tomography angiography
title_sort atherogenic index of plasma is associated with epicardial adipose tissue volume assessed on coronary computed tomography angiography
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187675/
https://www.ncbi.nlm.nih.gov/pubmed/35688850
http://dx.doi.org/10.1038/s41598-022-13479-5
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