Interaction between m6A methylation and noncoding RNA in glioma

Glioma is considered to be the most common brain malignancy in the central nervous system. At present, the aetiology of glioma is not clear. Due to its rapidly growth and easily recurrence, the prognosis of patients with glioma is very poor. N6-methyladenosine (m6A) methylation is an internal revers...

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Autores principales: Tao, Nairong, Wen, Tongxuan, Li, Tong, Luan, Lan, Pan, Hai, Wang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187709/
https://www.ncbi.nlm.nih.gov/pubmed/35688823
http://dx.doi.org/10.1038/s41420-022-01075-5
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author Tao, Nairong
Wen, Tongxuan
Li, Tong
Luan, Lan
Pan, Hai
Wang, Yong
author_facet Tao, Nairong
Wen, Tongxuan
Li, Tong
Luan, Lan
Pan, Hai
Wang, Yong
author_sort Tao, Nairong
collection PubMed
description Glioma is considered to be the most common brain malignancy in the central nervous system. At present, the aetiology of glioma is not clear. Due to its rapidly growth and easily recurrence, the prognosis of patients with glioma is very poor. N6-methyladenosine (m6A) methylation is an internal reversible modification in most RNAs, including messenger RNAs (mRNAs) and noncoding RNAs (ncRNAs). Recent studies have shown that the m6A regulators are abnormal expressed, and are extensively involved in the progression of glioma by targeting ncRNAs. Moreover, as the most important epigenetic regulators, ncRNAs can also affect the function of m6A regulators in glioma. This review summarized the expression and function of certain common m6A regulators in glioma. Also, the current review sum up the mutual interactions between m6A regulators and ncRNAs in glioma.
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spelling pubmed-91877092022-06-12 Interaction between m6A methylation and noncoding RNA in glioma Tao, Nairong Wen, Tongxuan Li, Tong Luan, Lan Pan, Hai Wang, Yong Cell Death Discov Review Article Glioma is considered to be the most common brain malignancy in the central nervous system. At present, the aetiology of glioma is not clear. Due to its rapidly growth and easily recurrence, the prognosis of patients with glioma is very poor. N6-methyladenosine (m6A) methylation is an internal reversible modification in most RNAs, including messenger RNAs (mRNAs) and noncoding RNAs (ncRNAs). Recent studies have shown that the m6A regulators are abnormal expressed, and are extensively involved in the progression of glioma by targeting ncRNAs. Moreover, as the most important epigenetic regulators, ncRNAs can also affect the function of m6A regulators in glioma. This review summarized the expression and function of certain common m6A regulators in glioma. Also, the current review sum up the mutual interactions between m6A regulators and ncRNAs in glioma. Nature Publishing Group UK 2022-06-10 /pmc/articles/PMC9187709/ /pubmed/35688823 http://dx.doi.org/10.1038/s41420-022-01075-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Tao, Nairong
Wen, Tongxuan
Li, Tong
Luan, Lan
Pan, Hai
Wang, Yong
Interaction between m6A methylation and noncoding RNA in glioma
title Interaction between m6A methylation and noncoding RNA in glioma
title_full Interaction between m6A methylation and noncoding RNA in glioma
title_fullStr Interaction between m6A methylation and noncoding RNA in glioma
title_full_unstemmed Interaction between m6A methylation and noncoding RNA in glioma
title_short Interaction between m6A methylation and noncoding RNA in glioma
title_sort interaction between m6a methylation and noncoding rna in glioma
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187709/
https://www.ncbi.nlm.nih.gov/pubmed/35688823
http://dx.doi.org/10.1038/s41420-022-01075-5
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