Orgo-Seq integrates single-cell and bulk transcriptomic data to identify cell type specific-driver genes associated with autism spectrum disorder

Cerebral organoids can be used to gain insights into cell type specific processes perturbed by genetic variants associated with neuropsychiatric disorders. However, robust and scalable phenotyping of organoids remains challenging. Here, we perform RNA sequencing on 71 samples comprising 1,420 cerebr...

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Detalles Bibliográficos
Autores principales: Lim, Elaine T., Chan, Yingleong, Dawes, Pepper, Guo, Xiaoge, Erdin, Serkan, Tai, Derek J. C., Liu, Songlei, Reichert, Julia M., Burns, Mannix J., Chan, Ying Kai, Chiang, Jessica J., Meyer, Katharina, Zhang, Xiaochang, Walsh, Christopher A., Yankner, Bruce A., Raychaudhuri, Soumya, Hirschhorn, Joel N., Gusella, James F., Talkowski, Michael E., Church, George M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187732/
https://www.ncbi.nlm.nih.gov/pubmed/35688811
http://dx.doi.org/10.1038/s41467-022-30968-3

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