Cargando…

A method for the controllable fabrication of optical fiber-based localized surface plasmon resonance sensors

Optical fiber-based Localized Surface Plasmon Resonance (OF-LSPR) biosensors have emerged as an ultra-sensitive miniaturized tool for a great variety of applications. Their fabrication by the chemical immobilization of gold nanoparticles (AuNPs) on the optic fiber end face is a simple and versatile...

Descripción completa

Detalles Bibliográficos
Autores principales: Calatayud-Sanchez, Alba, Ortega-Gomez, Angel, Barroso, Javier, Zubia, Joseba, Benito-Lopez, Fernando, Villatoro, Joel, Basabe-Desmonts, Lourdes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187767/
https://www.ncbi.nlm.nih.gov/pubmed/35688862
http://dx.doi.org/10.1038/s41598-022-13707-y
_version_ 1784725238537256960
author Calatayud-Sanchez, Alba
Ortega-Gomez, Angel
Barroso, Javier
Zubia, Joseba
Benito-Lopez, Fernando
Villatoro, Joel
Basabe-Desmonts, Lourdes
author_facet Calatayud-Sanchez, Alba
Ortega-Gomez, Angel
Barroso, Javier
Zubia, Joseba
Benito-Lopez, Fernando
Villatoro, Joel
Basabe-Desmonts, Lourdes
author_sort Calatayud-Sanchez, Alba
collection PubMed
description Optical fiber-based Localized Surface Plasmon Resonance (OF-LSPR) biosensors have emerged as an ultra-sensitive miniaturized tool for a great variety of applications. Their fabrication by the chemical immobilization of gold nanoparticles (AuNPs) on the optic fiber end face is a simple and versatile method. However, it can render poor reproducibility given the number of parameters that influence the binding of the AuNPs. In order to develop a method to obtain OF-LSPR sensors with high reproducibility, we studied the effect that factors such as temperature, AuNPs concentration, fiber core size and time of immersion had on the number and aggregation of AuNPs on the surface of the fibers and their resonance signal. Our method consisted in controlling the deposition of a determined AuNPs density on the tip of the fiber by measuring its LSPR signal (or plasmonic signal, Sp) in real-time. Sensors created thus were used to measure changes in the refractive index of their surroundings and the results showed that, as the number of AuNPs on the probes increased, the changes in the Sp maximum values were ever lower but the wavelength shifts were higher. These results highlighted the relevance of controlling the relationship between the sensor composition and its performance.
format Online
Article
Text
id pubmed-9187767
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-91877672022-06-12 A method for the controllable fabrication of optical fiber-based localized surface plasmon resonance sensors Calatayud-Sanchez, Alba Ortega-Gomez, Angel Barroso, Javier Zubia, Joseba Benito-Lopez, Fernando Villatoro, Joel Basabe-Desmonts, Lourdes Sci Rep Article Optical fiber-based Localized Surface Plasmon Resonance (OF-LSPR) biosensors have emerged as an ultra-sensitive miniaturized tool for a great variety of applications. Their fabrication by the chemical immobilization of gold nanoparticles (AuNPs) on the optic fiber end face is a simple and versatile method. However, it can render poor reproducibility given the number of parameters that influence the binding of the AuNPs. In order to develop a method to obtain OF-LSPR sensors with high reproducibility, we studied the effect that factors such as temperature, AuNPs concentration, fiber core size and time of immersion had on the number and aggregation of AuNPs on the surface of the fibers and their resonance signal. Our method consisted in controlling the deposition of a determined AuNPs density on the tip of the fiber by measuring its LSPR signal (or plasmonic signal, Sp) in real-time. Sensors created thus were used to measure changes in the refractive index of their surroundings and the results showed that, as the number of AuNPs on the probes increased, the changes in the Sp maximum values were ever lower but the wavelength shifts were higher. These results highlighted the relevance of controlling the relationship between the sensor composition and its performance. Nature Publishing Group UK 2022-06-10 /pmc/articles/PMC9187767/ /pubmed/35688862 http://dx.doi.org/10.1038/s41598-022-13707-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Calatayud-Sanchez, Alba
Ortega-Gomez, Angel
Barroso, Javier
Zubia, Joseba
Benito-Lopez, Fernando
Villatoro, Joel
Basabe-Desmonts, Lourdes
A method for the controllable fabrication of optical fiber-based localized surface plasmon resonance sensors
title A method for the controllable fabrication of optical fiber-based localized surface plasmon resonance sensors
title_full A method for the controllable fabrication of optical fiber-based localized surface plasmon resonance sensors
title_fullStr A method for the controllable fabrication of optical fiber-based localized surface plasmon resonance sensors
title_full_unstemmed A method for the controllable fabrication of optical fiber-based localized surface plasmon resonance sensors
title_short A method for the controllable fabrication of optical fiber-based localized surface plasmon resonance sensors
title_sort method for the controllable fabrication of optical fiber-based localized surface plasmon resonance sensors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187767/
https://www.ncbi.nlm.nih.gov/pubmed/35688862
http://dx.doi.org/10.1038/s41598-022-13707-y
work_keys_str_mv AT calatayudsanchezalba amethodforthecontrollablefabricationofopticalfiberbasedlocalizedsurfaceplasmonresonancesensors
AT ortegagomezangel amethodforthecontrollablefabricationofopticalfiberbasedlocalizedsurfaceplasmonresonancesensors
AT barrosojavier amethodforthecontrollablefabricationofopticalfiberbasedlocalizedsurfaceplasmonresonancesensors
AT zubiajoseba amethodforthecontrollablefabricationofopticalfiberbasedlocalizedsurfaceplasmonresonancesensors
AT benitolopezfernando amethodforthecontrollablefabricationofopticalfiberbasedlocalizedsurfaceplasmonresonancesensors
AT villatorojoel amethodforthecontrollablefabricationofopticalfiberbasedlocalizedsurfaceplasmonresonancesensors
AT basabedesmontslourdes amethodforthecontrollablefabricationofopticalfiberbasedlocalizedsurfaceplasmonresonancesensors
AT calatayudsanchezalba methodforthecontrollablefabricationofopticalfiberbasedlocalizedsurfaceplasmonresonancesensors
AT ortegagomezangel methodforthecontrollablefabricationofopticalfiberbasedlocalizedsurfaceplasmonresonancesensors
AT barrosojavier methodforthecontrollablefabricationofopticalfiberbasedlocalizedsurfaceplasmonresonancesensors
AT zubiajoseba methodforthecontrollablefabricationofopticalfiberbasedlocalizedsurfaceplasmonresonancesensors
AT benitolopezfernando methodforthecontrollablefabricationofopticalfiberbasedlocalizedsurfaceplasmonresonancesensors
AT villatorojoel methodforthecontrollablefabricationofopticalfiberbasedlocalizedsurfaceplasmonresonancesensors
AT basabedesmontslourdes methodforthecontrollablefabricationofopticalfiberbasedlocalizedsurfaceplasmonresonancesensors