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A method for the controllable fabrication of optical fiber-based localized surface plasmon resonance sensors
Optical fiber-based Localized Surface Plasmon Resonance (OF-LSPR) biosensors have emerged as an ultra-sensitive miniaturized tool for a great variety of applications. Their fabrication by the chemical immobilization of gold nanoparticles (AuNPs) on the optic fiber end face is a simple and versatile...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187767/ https://www.ncbi.nlm.nih.gov/pubmed/35688862 http://dx.doi.org/10.1038/s41598-022-13707-y |
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author | Calatayud-Sanchez, Alba Ortega-Gomez, Angel Barroso, Javier Zubia, Joseba Benito-Lopez, Fernando Villatoro, Joel Basabe-Desmonts, Lourdes |
author_facet | Calatayud-Sanchez, Alba Ortega-Gomez, Angel Barroso, Javier Zubia, Joseba Benito-Lopez, Fernando Villatoro, Joel Basabe-Desmonts, Lourdes |
author_sort | Calatayud-Sanchez, Alba |
collection | PubMed |
description | Optical fiber-based Localized Surface Plasmon Resonance (OF-LSPR) biosensors have emerged as an ultra-sensitive miniaturized tool for a great variety of applications. Their fabrication by the chemical immobilization of gold nanoparticles (AuNPs) on the optic fiber end face is a simple and versatile method. However, it can render poor reproducibility given the number of parameters that influence the binding of the AuNPs. In order to develop a method to obtain OF-LSPR sensors with high reproducibility, we studied the effect that factors such as temperature, AuNPs concentration, fiber core size and time of immersion had on the number and aggregation of AuNPs on the surface of the fibers and their resonance signal. Our method consisted in controlling the deposition of a determined AuNPs density on the tip of the fiber by measuring its LSPR signal (or plasmonic signal, Sp) in real-time. Sensors created thus were used to measure changes in the refractive index of their surroundings and the results showed that, as the number of AuNPs on the probes increased, the changes in the Sp maximum values were ever lower but the wavelength shifts were higher. These results highlighted the relevance of controlling the relationship between the sensor composition and its performance. |
format | Online Article Text |
id | pubmed-9187767 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-91877672022-06-12 A method for the controllable fabrication of optical fiber-based localized surface plasmon resonance sensors Calatayud-Sanchez, Alba Ortega-Gomez, Angel Barroso, Javier Zubia, Joseba Benito-Lopez, Fernando Villatoro, Joel Basabe-Desmonts, Lourdes Sci Rep Article Optical fiber-based Localized Surface Plasmon Resonance (OF-LSPR) biosensors have emerged as an ultra-sensitive miniaturized tool for a great variety of applications. Their fabrication by the chemical immobilization of gold nanoparticles (AuNPs) on the optic fiber end face is a simple and versatile method. However, it can render poor reproducibility given the number of parameters that influence the binding of the AuNPs. In order to develop a method to obtain OF-LSPR sensors with high reproducibility, we studied the effect that factors such as temperature, AuNPs concentration, fiber core size and time of immersion had on the number and aggregation of AuNPs on the surface of the fibers and their resonance signal. Our method consisted in controlling the deposition of a determined AuNPs density on the tip of the fiber by measuring its LSPR signal (or plasmonic signal, Sp) in real-time. Sensors created thus were used to measure changes in the refractive index of their surroundings and the results showed that, as the number of AuNPs on the probes increased, the changes in the Sp maximum values were ever lower but the wavelength shifts were higher. These results highlighted the relevance of controlling the relationship between the sensor composition and its performance. Nature Publishing Group UK 2022-06-10 /pmc/articles/PMC9187767/ /pubmed/35688862 http://dx.doi.org/10.1038/s41598-022-13707-y Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Calatayud-Sanchez, Alba Ortega-Gomez, Angel Barroso, Javier Zubia, Joseba Benito-Lopez, Fernando Villatoro, Joel Basabe-Desmonts, Lourdes A method for the controllable fabrication of optical fiber-based localized surface plasmon resonance sensors |
title | A method for the controllable fabrication of optical fiber-based localized surface plasmon resonance sensors |
title_full | A method for the controllable fabrication of optical fiber-based localized surface plasmon resonance sensors |
title_fullStr | A method for the controllable fabrication of optical fiber-based localized surface plasmon resonance sensors |
title_full_unstemmed | A method for the controllable fabrication of optical fiber-based localized surface plasmon resonance sensors |
title_short | A method for the controllable fabrication of optical fiber-based localized surface plasmon resonance sensors |
title_sort | method for the controllable fabrication of optical fiber-based localized surface plasmon resonance sensors |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187767/ https://www.ncbi.nlm.nih.gov/pubmed/35688862 http://dx.doi.org/10.1038/s41598-022-13707-y |
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