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Retinal Pigment Epithelium in Human Donor Eyes Contains Higher Levels of Bisretinoids Including A2E in Periphery than Macula

PURPOSE: With age, human retinal pigment epithelium (RPE) accumulates bisretinoid fluorophores that may impact cellular function and contribute to age-related macular degeneration (AMD). Bisretinoids are comprised of a central pyridinium, dihydropyridinium, or cyclohexadiene ring. The pyridinium bis...

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Detalles Bibliográficos
Autores principales:	Kotnala, Ankita, Senthilkumari, Srinivasan, Wu, Gong, Stewart, Thomas G., Curcio, Christine A., Halder, Nabanita, Singh, Sundararajan Baskar, Kumar, Atul, Velpandian, Thirumurthy
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2022
Materias:	Biochemistry and Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9187938/ https://www.ncbi.nlm.nih.gov/pubmed/35671050 http://dx.doi.org/10.1167/iovs.63.6.6

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