Activating cGAS–STING axis contributes to neuroinflammation in CVST mouse model and induces inflammasome activation and microglia pyroptosis

BACKGROUND: Neuroinflammation-induced injury is intimately associated with poor prognosis in patients with cerebral venous sinus thrombosis (CVST). The cyclic GMP-AMP synthase–stimulator of interferon gene (cGAS–STING) axis is a cytoplasmic double-stranded DNA (dsDNA) sensing pathway has recently em...

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Detalles Bibliográficos
Autores principales: Ding, Rui, Li, Haiyan, Liu, Yaqi, Ou, Weiyang, Zhang, Xifang, Chai, Huihui, Huang, Xiaofei, Yang, Weijie, Wang, Qiujing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188164/
https://www.ncbi.nlm.nih.gov/pubmed/35689216
http://dx.doi.org/10.1186/s12974-022-02511-0

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