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Lactate in contemporary biology: a phoenix risen
After a century, it's time to turn the page on understanding of lactate metabolism and appreciate that lactate shuttling is an important component of intermediary metabolism in vivo. Cell‐cell and intracellular lactate shuttles fulfil purposes of energy substrate production and distribution, as...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188361/ https://www.ncbi.nlm.nih.gov/pubmed/33566386 http://dx.doi.org/10.1113/JP280955 |
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author | Brooks, George A. Arevalo, Jose A. Osmond, Adam D. Leija, Robert G. Curl, Casey C. Tovar, Ashley P. |
author_facet | Brooks, George A. Arevalo, Jose A. Osmond, Adam D. Leija, Robert G. Curl, Casey C. Tovar, Ashley P. |
author_sort | Brooks, George A. |
collection | PubMed |
description | After a century, it's time to turn the page on understanding of lactate metabolism and appreciate that lactate shuttling is an important component of intermediary metabolism in vivo. Cell‐cell and intracellular lactate shuttles fulfil purposes of energy substrate production and distribution, as well as cell signalling under fully aerobic conditions. Recognition of lactate shuttling came first in studies of physical exercise where the roles of driver (producer) and recipient (consumer) cells and tissues were obvious. Moreover, the presence of lactate shuttling as part of postprandial glucose disposal and satiety signalling has been recognized. Mitochondrial respiration creates the physiological sink for lactate disposal in vivo. Repeated lactate exposure from regular exercise results in adaptive processes such as mitochondrial biogenesis and other healthful circulatory and neurological characteristics such as improved physical work capacity, metabolic flexibility, learning, and memory. The importance of lactate and lactate shuttling in healthful living is further emphasized when lactate signalling and shuttling are dysregulated as occurs in particular illnesses and injuries. Like a phoenix, lactate has risen to major importance in 21st century biology. [Image: see text] |
format | Online Article Text |
id | pubmed-9188361 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-91883612022-06-11 Lactate in contemporary biology: a phoenix risen Brooks, George A. Arevalo, Jose A. Osmond, Adam D. Leija, Robert G. Curl, Casey C. Tovar, Ashley P. J Physiol Reviews After a century, it's time to turn the page on understanding of lactate metabolism and appreciate that lactate shuttling is an important component of intermediary metabolism in vivo. Cell‐cell and intracellular lactate shuttles fulfil purposes of energy substrate production and distribution, as well as cell signalling under fully aerobic conditions. Recognition of lactate shuttling came first in studies of physical exercise where the roles of driver (producer) and recipient (consumer) cells and tissues were obvious. Moreover, the presence of lactate shuttling as part of postprandial glucose disposal and satiety signalling has been recognized. Mitochondrial respiration creates the physiological sink for lactate disposal in vivo. Repeated lactate exposure from regular exercise results in adaptive processes such as mitochondrial biogenesis and other healthful circulatory and neurological characteristics such as improved physical work capacity, metabolic flexibility, learning, and memory. The importance of lactate and lactate shuttling in healthful living is further emphasized when lactate signalling and shuttling are dysregulated as occurs in particular illnesses and injuries. Like a phoenix, lactate has risen to major importance in 21st century biology. [Image: see text] John Wiley and Sons Inc. 2021-02-25 2022-03-01 /pmc/articles/PMC9188361/ /pubmed/33566386 http://dx.doi.org/10.1113/JP280955 Text en © 2021 The Authors. The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Reviews Brooks, George A. Arevalo, Jose A. Osmond, Adam D. Leija, Robert G. Curl, Casey C. Tovar, Ashley P. Lactate in contemporary biology: a phoenix risen |
title | Lactate in contemporary biology: a phoenix risen |
title_full | Lactate in contemporary biology: a phoenix risen |
title_fullStr | Lactate in contemporary biology: a phoenix risen |
title_full_unstemmed | Lactate in contemporary biology: a phoenix risen |
title_short | Lactate in contemporary biology: a phoenix risen |
title_sort | lactate in contemporary biology: a phoenix risen |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188361/ https://www.ncbi.nlm.nih.gov/pubmed/33566386 http://dx.doi.org/10.1113/JP280955 |
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