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Regular Late Bedtime Significantly Affects the Skin Physiological Characteristics and Skin Bacterial Microbiome
BACKGROUND: Late bedtime is a common form of unhealthy sleep pattern in adulthood, which influences circadian rhythm, and negatively affects health. However, little is known about the effect of regular late bedtime on skin characteristics, particularly on skin microbiome. OBJECTIVE: To investigate t...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188400/ https://www.ncbi.nlm.nih.gov/pubmed/35698548 http://dx.doi.org/10.2147/CCID.S364542 |
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author | Shao, Li Jiang, Sujing Li, Yan Shi, Yanqin Wang, Man Liu, Ting Yang, Suzhen Ma, Laiji |
author_facet | Shao, Li Jiang, Sujing Li, Yan Shi, Yanqin Wang, Man Liu, Ting Yang, Suzhen Ma, Laiji |
author_sort | Shao, Li |
collection | PubMed |
description | BACKGROUND: Late bedtime is a common form of unhealthy sleep pattern in adulthood, which influences circadian rhythm, and negatively affects health. However, little is known about the effect of regular late bedtime on skin characteristics, particularly on skin microbiome. OBJECTIVE: To investigate the changes and effects of the regular late bedtime on skin physiological parameters and facial bacterial microbiome of 219 cases of Chinese women aged 18–38 years living in Shanghai. METHODS: Based on the Self-Evaluation Questionnaire, bedtime was categorized as 11:00 PM; thus, the volunteers were divided into early bedtime group (S0) and late bedtime group (S1). The physiological parameters of facial skin were measured by non-invasive instrumental methods, and the skin microbiome was analyzed by 16S rRNA high-throughput sequencing. RESULTS: The skin physiological parameters of the late bedtime group exhibited significant decrease in skin hydration content, skin firmness (F4) and elasticity (R2), while TEWL, sebum and wrinkle significantly increased. The result indicated that late bedtime significantly impaired the integrity of skin barrier, damaged skin structure, and disrupted water–oil balance. Furthermore, the analysis of α-diversity, Sobs, Ace and Chao index were found to significantly decrease (P < 0.05) in the late bedtime group, suggesting that late bedtime reduced both the abundance and the diversity of facial bacterial microbiota. Moreover, the abundance of Pseudomonas increased significantly, while Streptococcus, Stenotrophomonas, Acinetobacter, Haemophilus, Actinomyces and Neisseria decreased significantly. In addition, Spearman correlation analysis revealed strong correlations between the microbiota and the physiological parameters. Notably, the abundance of Pseudomonas significantly positively correlated with skin firmness and elasticity, but significantly negatively correlated with skin hemoglobin content, melanin content and skin hydration. CONCLUSION: Bedtime is an important factor in maintaining skin health. Regular late bedtime not only damages the skin barrier and skin structure but also reduces the diversity and composition of facial bacterial microbiome. |
format | Online Article Text |
id | pubmed-9188400 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-91884002022-06-12 Regular Late Bedtime Significantly Affects the Skin Physiological Characteristics and Skin Bacterial Microbiome Shao, Li Jiang, Sujing Li, Yan Shi, Yanqin Wang, Man Liu, Ting Yang, Suzhen Ma, Laiji Clin Cosmet Investig Dermatol Original Research BACKGROUND: Late bedtime is a common form of unhealthy sleep pattern in adulthood, which influences circadian rhythm, and negatively affects health. However, little is known about the effect of regular late bedtime on skin characteristics, particularly on skin microbiome. OBJECTIVE: To investigate the changes and effects of the regular late bedtime on skin physiological parameters and facial bacterial microbiome of 219 cases of Chinese women aged 18–38 years living in Shanghai. METHODS: Based on the Self-Evaluation Questionnaire, bedtime was categorized as 11:00 PM; thus, the volunteers were divided into early bedtime group (S0) and late bedtime group (S1). The physiological parameters of facial skin were measured by non-invasive instrumental methods, and the skin microbiome was analyzed by 16S rRNA high-throughput sequencing. RESULTS: The skin physiological parameters of the late bedtime group exhibited significant decrease in skin hydration content, skin firmness (F4) and elasticity (R2), while TEWL, sebum and wrinkle significantly increased. The result indicated that late bedtime significantly impaired the integrity of skin barrier, damaged skin structure, and disrupted water–oil balance. Furthermore, the analysis of α-diversity, Sobs, Ace and Chao index were found to significantly decrease (P < 0.05) in the late bedtime group, suggesting that late bedtime reduced both the abundance and the diversity of facial bacterial microbiota. Moreover, the abundance of Pseudomonas increased significantly, while Streptococcus, Stenotrophomonas, Acinetobacter, Haemophilus, Actinomyces and Neisseria decreased significantly. In addition, Spearman correlation analysis revealed strong correlations between the microbiota and the physiological parameters. Notably, the abundance of Pseudomonas significantly positively correlated with skin firmness and elasticity, but significantly negatively correlated with skin hemoglobin content, melanin content and skin hydration. CONCLUSION: Bedtime is an important factor in maintaining skin health. Regular late bedtime not only damages the skin barrier and skin structure but also reduces the diversity and composition of facial bacterial microbiome. Dove 2022-06-07 /pmc/articles/PMC9188400/ /pubmed/35698548 http://dx.doi.org/10.2147/CCID.S364542 Text en © 2022 Shao et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Shao, Li Jiang, Sujing Li, Yan Shi, Yanqin Wang, Man Liu, Ting Yang, Suzhen Ma, Laiji Regular Late Bedtime Significantly Affects the Skin Physiological Characteristics and Skin Bacterial Microbiome |
title | Regular Late Bedtime Significantly Affects the Skin Physiological Characteristics and Skin Bacterial Microbiome |
title_full | Regular Late Bedtime Significantly Affects the Skin Physiological Characteristics and Skin Bacterial Microbiome |
title_fullStr | Regular Late Bedtime Significantly Affects the Skin Physiological Characteristics and Skin Bacterial Microbiome |
title_full_unstemmed | Regular Late Bedtime Significantly Affects the Skin Physiological Characteristics and Skin Bacterial Microbiome |
title_short | Regular Late Bedtime Significantly Affects the Skin Physiological Characteristics and Skin Bacterial Microbiome |
title_sort | regular late bedtime significantly affects the skin physiological characteristics and skin bacterial microbiome |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188400/ https://www.ncbi.nlm.nih.gov/pubmed/35698548 http://dx.doi.org/10.2147/CCID.S364542 |
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