Cargando…

Bioinformatic Analysis of the Expression and Clinical Significance of the DNA Replication Regulator MCM Complex in Bladder Cancer

OBJECTIVE: The minichromosome maintenance (MCM) complex (MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7), which regulates DNA replication and cell cycle progression, is essential for the development and progression of multiple tumors, but their role in bladder cancer development remains unclear. In the pres...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Ru, Hu, Bing, Jiang, Ming, Deng, Wen, Zheng, Ping, Fu, Bin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188401/ https://www.ncbi.nlm.nih.gov/pubmed/35698656 http://dx.doi.org/10.2147/IJGM.S368573

Ejemplares similares

Identification of the DNA Replication Regulator MCM Complex Expression and Prognostic Significance in Hepatic Carcinoma
por: Cao, Ting, et al.
Publicado: (2020)

DNA translocation mechanism of the MCM complex and implications for replication initiation
por: Meagher, Martin, et al.
Publicado: (2019)

The assembly of the MCM2–7 hetero-hexamer and its significance in DNA replication
por: Hatoyama, Yuki, et al.
Publicado: (2023)

The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication
por: Aparicio, Tomás, et al.
Publicado: (2009)

Mcm8 and Mcm9 form a dimeric complex in Xenopus laevis egg extract that is not essential for DNA replication initiation
por: Gambus, Agnieszka, et al.
Publicado: (2013)

Ancient diversification of eukaryotic MCM DNA replication proteins
por: Liu, Yuan, et al.
Publicado: (2009)

Recruitment of Mcm10 to Sites of Replication Initiation Requires Direct Binding to the Minichromosome Maintenance (MCM) Complex
por: Douglas, Max E., et al.
Publicado: (2016)

Mcm10 regulates DNA replication elongation by stimulating the CMG replicative helicase
por: Lõoke, Marko, et al.
Publicado: (2017)

Comprehensive Analysis of the Expression, Prognosis, and Biological Significance of PLOD Family in Bladder Cancer
por: Chen, Ru, et al.
Publicado: (2023)

Systemic Analysis of the DNA Replication Regulator MCM Complex in Ovarian Cancer and Its Prognostic Value
por: Li, Yukun, et al.
Publicado: (2021)

Differential Requirements for MCM Proteins in DNA Replication in Drosophila S2 Cells
por: Crevel, Gilles, et al.
Publicado: (2007)

Drosophila Mcm10 Is Required for DNA Replication and Differentiation in the Compound Eye
por: Vo, Nicole, et al.
Publicado: (2014)

A new MCM modification cycle regulates DNA replication initiation
por: Wei, Lei, et al.
Publicado: (2016)

Phosphorylated STAT5 directly facilitates parvovirus B19 DNA replication in human erythroid progenitors through interaction with the MCM complex
por: Ganaie, Safder S., et al.
Publicado: (2017)

Cdc45-MCM-GINS, a new power player for DNA replication
por: Aparicio, Tomás, et al.
Publicado: (2006)

How MCM loading and spreading specify eukaryotic DNA replication initiation sites
por: Hyrien, Olivier
Publicado: (2016)

Genome-wide function of MCM-BP in Trypanosoma brucei DNA replication and transcription
por: Kim, Hee-Sook
Publicado: (2019)

Rif1 controls DNA replication by directing Protein Phosphatase 1 to reverse Cdc7-mediated phosphorylation of the MCM complex
por: Hiraga, Shin-ichiro, et al.
Publicado: (2014)

Mcm2 phosphorylation and the response to replicative stress
por: Stead, Brent E, et al.
Publicado: (2012)

Identification of the Expression and Clinical Significance of E2F Family in Clear Cell Renal Cell Carcinoma
por: Chen, Ru, et al.
Publicado: (2022)

Significance of DNA Replication Licensing Proteins (MCM2, MCM5 and CDC6), p16 and p63 as Markers of Premalignant Lesions of the Uterine Cervix: Its Usefulness to Predict Malignant Potential
por: Saritha, VN, et al.
Publicado: (2018)

Deregulated Cdc6 inhibits DNA replication and suppresses Cdc7-mediated phosphorylation of Mcm2–7 complex
por: Kundu, Lena R., et al.
Publicado: (2010)

Juvenile Hormone-Receptor Complex Acts on Mcm4 and Mcm7 to Promote Polyploidy and Vitellogenesis in the Migratory Locust
por: Guo, Wei, et al.
Publicado: (2014)

A conserved MCM single-stranded DNA binding element is essential for replication initiation
por: Froelich, Clifford A, et al.
Publicado: (2014)

Ciprofloxacin is an inhibitor of the Mcm2-7 replicative helicase
por: Simon, Nicholas, et al.
Publicado: (2013)

The Cdc45/RecJ-like protein forms a complex with GINS and MCM, and is important for DNA replication in Thermococcus kodakarensis
por: Nagata, Mariko, et al.
Publicado: (2017)

O-GlcNAc transferase associates with the MCM2–7 complex and its silencing destabilizes MCM–MCM interactions
por: Leturcq, Maïté, et al.
Publicado: (2018)

Interactions of the Human MCM-BP Protein with MCM Complex Components and Dbf4
por: Nguyen, Tin, et al.
Publicado: (2012)

Mechanism and Timing of Mcm2–7 Ring Closure During DNA Replication Origin Licensing
por: Ticau, Simina, et al.
Publicado: (2017)

Mechanism of DNA unwinding by hexameric MCM8–9 in complex with HROB
por: Acharya, Ananya, et al.
Publicado: (2023)

Human SIRT1 regulates DNA binding and stability of the Mcm10 DNA replication factor via deacetylation
por: Fatoba, Samuel T., et al.
Publicado: (2013)

The CMG (CDC45/RecJ, MCM, GINS) complex is a conserved component of the DNA replication system in all archaea and eukaryotes
por: Makarova, Kira S, et al.
Publicado: (2012)

Down-regulation of CK2α correlates with decreased expression levels of DNA replication minichromosome maintenance protein complex (MCM) genes
por: Schaefer, Susanne, et al.
Publicado: (2019)

Decreased MCM2-6 in Drosophila S2 Cells Does Not Generate Significant DNA Damage or Cause a Marked Increase in Sensitivity to Replication Interference
por: Crevel, Isabelle, et al.
Publicado: (2011)

MCM Paradox: Abundance of Eukaryotic Replicative Helicases and Genomic Integrity
por: Das, Mitali, et al.
Publicado: (2014)

Mcm10: A Dynamic Scaffold at Eukaryotic Replication Forks
por: Baxley, Ryan M., et al.
Publicado: (2017)

The capacity of origins to load MCM establishes replication timing patterns
por: Dukaj, Livio, et al.
Publicado: (2021)

Interaction of RECQ4 and MCM10 is important for efficient DNA replication origin firing in human cells
por: Kliszczak, Maciej, et al.
Publicado: (2015)

Acute inactivation of the replicative helicase in human cells triggers MCM8–9-dependent DNA synthesis
por: Natsume, Toyoaki, et al.
Publicado: (2017)

MCM10 compensates for Myc‐induced DNA replication stress in breast cancer stem‐like cells
por: Murayama, Takahiko, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_o8skkc3i3vck4cqg38cob4ikat