Antigen glycosylation regulates efficacy of CAR T cells targeting CD19

While chimeric antigen receptor (CAR) T cells targeting CD19 can cure a subset of patients with B cell malignancies, most patients treated will not achieve durable remission. Identification of the mechanisms leading to failure is essential to broadening the efficacy of this promising platform. Sever...

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Detalles Bibliográficos
Autores principales: Heard, Amanda, Landmann, Jack H., Hansen, Ava R., Papadopolou, Alkmini, Hsu, Yu-Sung, Selli, Mehmet Emrah, Warrington, John M., Lattin, John, Chang, Jufang, Ha, Helen, Haug-Kroeper, Martina, Doray, Balraj, Gill, Saar, Ruella, Marco, Hayer, Katharina E., Weitzman, Matthew D., Green, Abby M., Fluhrer, Regina, Singh, Nathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188573/
https://www.ncbi.nlm.nih.gov/pubmed/35690611
http://dx.doi.org/10.1038/s41467-022-31035-7

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