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Pachymetric Assessment After EpiSmart(®) Epithelium-on Cross-Linking for Keratoconus and Post-Surgical Ectasia
PURPOSE: To assess the change in corneal pachymetry after a novel epithelium-on (EpiSmart(®)) corneal crosslinking procedure (CXL). METHODS: Eyes treated as part of the open-label, non-controlled arm of the study “Collagen Crosslinking with Ultraviolet-A in Asymmetric Corneas” (NCT01097447) were exa...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188777/ https://www.ncbi.nlm.nih.gov/pubmed/35702687 http://dx.doi.org/10.2147/OPTH.S359710 |
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author | Vaidya, Neel S Daneshmand, Arvin Epstein, Randy J Majmudar, Parag A Belin, Michael W Parsons, Edward C Rubinfeld, Roy S |
author_facet | Vaidya, Neel S Daneshmand, Arvin Epstein, Randy J Majmudar, Parag A Belin, Michael W Parsons, Edward C Rubinfeld, Roy S |
author_sort | Vaidya, Neel S |
collection | PubMed |
description | PURPOSE: To assess the change in corneal pachymetry after a novel epithelium-on (EpiSmart(®)) corneal crosslinking procedure (CXL). METHODS: Eyes treated as part of the open-label, non-controlled arm of the study “Collagen Crosslinking with Ultraviolet-A in Asymmetric Corneas” (NCT01097447) were examined at baseline, 3-, 6- and 12-months post-CXL. Thinnest pachymetry readings based on Pentacam (OCULUS GmbH, Wetzlar, Germany) were recorded. RESULTS: A total of 101 eyes met the study inclusion criteria. Thinnest pachymetric readings at baseline averaged 451 ± 50 microns. The mean (± SD) minimum thickness was 450 ± 46 microns at 3 months, 452 ± 47 microns at 6 months, and 451 ± 48 microns at 12 months post-CXL. The changes from baseline (mean ± SE) at 3, 6, and 12 months post-CXL were −1.2 ± 1.5 microns, 0.5 ± 1.6 microns, and 0.4 ± 1.6 microns, respectively. Student’s t-tests showed no statistically significant change in pachymetry from baseline for any exam period. CONCLUSION: This study demonstrated that, after EpiSmart(®) epithelium-on CXL, there was no substantial corneal thinning observable on Scheimpflug tomography out to 12 months. |
format | Online Article Text |
id | pubmed-9188777 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-91887772022-06-13 Pachymetric Assessment After EpiSmart(®) Epithelium-on Cross-Linking for Keratoconus and Post-Surgical Ectasia Vaidya, Neel S Daneshmand, Arvin Epstein, Randy J Majmudar, Parag A Belin, Michael W Parsons, Edward C Rubinfeld, Roy S Clin Ophthalmol Original Research PURPOSE: To assess the change in corneal pachymetry after a novel epithelium-on (EpiSmart(®)) corneal crosslinking procedure (CXL). METHODS: Eyes treated as part of the open-label, non-controlled arm of the study “Collagen Crosslinking with Ultraviolet-A in Asymmetric Corneas” (NCT01097447) were examined at baseline, 3-, 6- and 12-months post-CXL. Thinnest pachymetry readings based on Pentacam (OCULUS GmbH, Wetzlar, Germany) were recorded. RESULTS: A total of 101 eyes met the study inclusion criteria. Thinnest pachymetric readings at baseline averaged 451 ± 50 microns. The mean (± SD) minimum thickness was 450 ± 46 microns at 3 months, 452 ± 47 microns at 6 months, and 451 ± 48 microns at 12 months post-CXL. The changes from baseline (mean ± SE) at 3, 6, and 12 months post-CXL were −1.2 ± 1.5 microns, 0.5 ± 1.6 microns, and 0.4 ± 1.6 microns, respectively. Student’s t-tests showed no statistically significant change in pachymetry from baseline for any exam period. CONCLUSION: This study demonstrated that, after EpiSmart(®) epithelium-on CXL, there was no substantial corneal thinning observable on Scheimpflug tomography out to 12 months. Dove 2022-06-08 /pmc/articles/PMC9188777/ /pubmed/35702687 http://dx.doi.org/10.2147/OPTH.S359710 Text en © 2022 Vaidya et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Original Research Vaidya, Neel S Daneshmand, Arvin Epstein, Randy J Majmudar, Parag A Belin, Michael W Parsons, Edward C Rubinfeld, Roy S Pachymetric Assessment After EpiSmart(®) Epithelium-on Cross-Linking for Keratoconus and Post-Surgical Ectasia |
title | Pachymetric Assessment After EpiSmart(®) Epithelium-on Cross-Linking for Keratoconus and Post-Surgical Ectasia |
title_full | Pachymetric Assessment After EpiSmart(®) Epithelium-on Cross-Linking for Keratoconus and Post-Surgical Ectasia |
title_fullStr | Pachymetric Assessment After EpiSmart(®) Epithelium-on Cross-Linking for Keratoconus and Post-Surgical Ectasia |
title_full_unstemmed | Pachymetric Assessment After EpiSmart(®) Epithelium-on Cross-Linking for Keratoconus and Post-Surgical Ectasia |
title_short | Pachymetric Assessment After EpiSmart(®) Epithelium-on Cross-Linking for Keratoconus and Post-Surgical Ectasia |
title_sort | pachymetric assessment after epismart(®) epithelium-on cross-linking for keratoconus and post-surgical ectasia |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9188777/ https://www.ncbi.nlm.nih.gov/pubmed/35702687 http://dx.doi.org/10.2147/OPTH.S359710 |
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